Ti/Ta-based composite polysaccharide scaffolds for guided bone regeneration in total hip arthroplasty

Guided bone regeneration can play an important role in orthopedic applications. This work presents the synthesis and characterization of composite scaffolds based on polysaccharides loaded with microparticles of titanium or tantalum as novel materials proposed for composite systems with promising characteristics for guided bone regeneration. Ti/Ta composite scaffolds were synthesized using chitosan and gellan gum as organic substrates and crosslinked with oxidized dextran resulting in stable inorganic-organic composites. Physico-chemical characterization revealed a uniform distribution of metal nanoparticles within the scaffolds that showed a release of metals lower than 5 %. In vitro biological assays demonstrated that Ta composites exhibit a 2 times higher ALP activity than Ti and a higher capacity to support the full differentiation of human mesenchymal stem cells into osteoblasts. These results highlight their potential for bone regeneration applications. [Display omitted] •Novel composite scaffolds based on polysaccharides and titanium or tantalum were synthesized for bone defect regeneration.•Both Ti and Ta-loaded composites exhibited comparable physiochemical properties and high biocompatibility.•Ta-scaffolds demonstrated superior osteoconductivity over Ti-scaffolds, supporting stem cell differentiation into osteoblasts.•Ta composites emerged as a promising material for bone regeneration applications, particularly in total hip arthroplasty.