Interleukin 21 promotes IgG1+ plasma cell differentiation instead of class switching to IgE via Blimp1 expression

IgE is induced by the presence of IL‐4 by class switching from IgM through IgG1 to IgE. IL‐21 inhibits the IgE class switch by induction of Blimp1 leading to Stat6 and AID downregulation, and plasmablast/plasma cell differentiation.

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Bibliographische Detailangaben
Veröffentlicht in:	European journal of immunology 2024-08, Vol.54 (8), p.e2451041-n/a
Hauptverfasser:	Hashiguchi, Masaaki, Asatsuma‐Okumura, Tomoko, Iwai, Yoshiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell differentiation Cell Differentiation - immunology Class switch Class switching IgE IgG1 IL‐21 Immunoglobulin Class Switching Immunoglobulin E Immunoglobulin E - immunology Immunoglobulin G Immunoglobulin G - immunology Immunoglobulin M Interleukin 21 Interleukin-4 - immunology Interleukin-4 - metabolism Interleukins - immunology Interleukins - metabolism Mice Plasma cell Plasma Cells - immunology Positive Regulatory Domain I-Binding Factor 1 - genetics Positive Regulatory Domain I-Binding Factor 1 - metabolism Stat6 protein
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Beschreibung
Zusammenfassung:	IgE is induced by the presence of IL‐4 by class switching from IgM through IgG1 to IgE. IL‐21 inhibits the IgE class switch by induction of Blimp1 leading to Stat6 and AID downregulation, and plasmablast/plasma cell differentiation.
ISSN:	0014-2980 1521-4141 1521-4141
DOI:	10.1002/eji.202451041