Short‐chain fatty acids: bridges between diet, gut microbiota, and health

In recent years, gut microbiota has become a hot topic in the fields of medicine and life sciences. Short‐chain fatty acids (SCFAs), the main metabolites of gut microbiota produced by microbial fermentation of dietary fiber, play a vital role in healthy and ill hosts. SCFAs regulate the process of m...

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Veröffentlicht in:Journal of gastroenterology and hepatology 2024-09, Vol.39 (9), p.1728-1736
Hauptverfasser: Wang, Ling‐Yun, He, Li‐Hong, Xu, Li‐Jun, Li, Shi‐Bo
Format: Artikel
Sprache:eng
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Zusammenfassung:In recent years, gut microbiota has become a hot topic in the fields of medicine and life sciences. Short‐chain fatty acids (SCFAs), the main metabolites of gut microbiota produced by microbial fermentation of dietary fiber, play a vital role in healthy and ill hosts. SCFAs regulate the process of metabolism, immune, and inflammation and have therapeutic effects on gastrointestinal and neurological disorders, as well as antitumor properties. This review summarized the production, distribution, and molecular mechanism of SCFAs, as well as their mechanisms of action in healthy and ill hosts. In addition, we also emphasized the negative effects of SCFAs, aiming to provide the public with a more comprehensive understanding of SCFAs.
ISSN:0815-9319
1440-1746
1440-1746
DOI:10.1111/jgh.16619