Lower risk of low bone mineral density in high vitamin E level in older people: A cross-sectional study
Osteoporosis and osteopenia, together known as low bone mineral density (LBMD), are common problems in the elderly. LBMD may cause fragility fractures in the elderly. The relationship between Vitamin E and LBMD in old Americans is still unclear. In this study, we investigated the relationship betwee...
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| Veröffentlicht in: | Clinical nutrition ESPEN 2024-06, Vol.61, p.316-321 |
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| creator | Peng, Ying-Long Wang, Zi-Yan Wang, Xuan-Jia Ji, Yu-Tong Wen, Yaqing Mai, Yanpei |
| description | Osteoporosis and osteopenia, together known as low bone mineral density (LBMD), are common problems in the elderly. LBMD may cause fragility fractures in the elderly. The relationship between Vitamin E and LBMD in old Americans is still unclear. In this study, we investigated the relationship between serum Vitamin E levels and LBMD in the elderly.
We utilized data from the National Health and Nutrition Examination Survey (NHANES) 2017–2018 and ultimately included 378 participants aged 50 to 79. Multivariable logistic or linear regression models were applied to examine the associations between serum Vitamin E levels and LBMD, total femur or lumbar spine BMD after adjusting for covariates.
After adjusting for all covariates, higher serum Vitamin E levels reduced the risk of LBMD (OR 0.76; 95% CI 0.58–1.00) and were positively associated with total femur BMD (β: 0.02; 95% CI: 0.01–0.03)， after adjusting for all covariates. In the subgroup analysis, for the BMI normal group (BMI |
| doi_str_mv | 10.1016/j.clnesp.2024.04.006 |
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We utilized data from the National Health and Nutrition Examination Survey (NHANES) 2017–2018 and ultimately included 378 participants aged 50 to 79. Multivariable logistic or linear regression models were applied to examine the associations between serum Vitamin E levels and LBMD, total femur or lumbar spine BMD after adjusting for covariates.
After adjusting for all covariates, higher serum Vitamin E levels reduced the risk of LBMD (OR 0.76; 95% CI 0.58–1.00) and were positively associated with total femur BMD (β: 0.02; 95% CI: 0.01–0.03)， after adjusting for all covariates. In the subgroup analysis, for the BMI normal group (BMI<25), the serum Vitamin E levels were positively associated with the total femur (β: 0.03; 95% CI: 0.01–0.05) and lumbar spine BMD (β: 0.04; 95% CI: 0.01–0.07). In the BMI normal group, people with high serum Vitamin E levels have a lower incidence of LBMD (OR:0.43; 95% CI: 0.21–0.88). Though the P for interaction was larger than 0.05.
This study found serum Vitamin E levels were negatively associated with LBMD in older Americans. Serum Vitamin E levels were positively associated with femur BMD in older Americans.</description><identifier>ISSN: 2405-4577</identifier><identifier>EISSN: 2405-4577</identifier><identifier>DOI: 10.1016/j.clnesp.2024.04.006</identifier><identifier>PMID: 38777450</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Aged ; blood serum ; Bone Density ; Bone Diseases, Metabolic - blood ; Bone Diseases, Metabolic - epidemiology ; Bone mineral density ; clinical nutrition ; Cross-Sectional Studies ; Elderly ; Female ; Femur ; Humans ; lumbar spine ; Lumbar Vertebrae ; Male ; Middle Aged ; National Health and Nutrition Examination Survey ; Nutrition Surveys ; Osteopenia ; Osteoporosis ; Osteoporosis - blood ; people ; regression analysis ; risk ; Risk Factors ; Vitamin E ; Vitamin E - blood</subject><ispartof>Clinical nutrition ESPEN, 2024-06, Vol.61, p.316-321</ispartof><rights>2024 European Society for Clinical Nutrition and Metabolism</rights><rights>Copyright © 2024 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c344t-76eb931ff3da76b8569cdf787341bab19b721d9d3f421d1bda57c72a06190c933</cites><orcidid>0009-0009-8924-985X ; 0000-0002-7162-4422</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38777450$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peng, Ying-Long</creatorcontrib><creatorcontrib>Wang, Zi-Yan</creatorcontrib><creatorcontrib>Wang, Xuan-Jia</creatorcontrib><creatorcontrib>Ji, Yu-Tong</creatorcontrib><creatorcontrib>Wen, Yaqing</creatorcontrib><creatorcontrib>Mai, Yanpei</creatorcontrib><title>Lower risk of low bone mineral density in high vitamin E level in older people: A cross-sectional study</title><title>Clinical nutrition ESPEN</title><addtitle>Clin Nutr ESPEN</addtitle><description>Osteoporosis and osteopenia, together known as low bone mineral density (LBMD), are common problems in the elderly. LBMD may cause fragility fractures in the elderly. The relationship between Vitamin E and LBMD in old Americans is still unclear. In this study, we investigated the relationship between serum Vitamin E levels and LBMD in the elderly.
We utilized data from the National Health and Nutrition Examination Survey (NHANES) 2017–2018 and ultimately included 378 participants aged 50 to 79. Multivariable logistic or linear regression models were applied to examine the associations between serum Vitamin E levels and LBMD, total femur or lumbar spine BMD after adjusting for covariates.
After adjusting for all covariates, higher serum Vitamin E levels reduced the risk of LBMD (OR 0.76; 95% CI 0.58–1.00) and were positively associated with total femur BMD (β: 0.02; 95% CI: 0.01–0.03)， after adjusting for all covariates. In the subgroup analysis, for the BMI normal group (BMI<25), the serum Vitamin E levels were positively associated with the total femur (β: 0.03; 95% CI: 0.01–0.05) and lumbar spine BMD (β: 0.04; 95% CI: 0.01–0.07). In the BMI normal group, people with high serum Vitamin E levels have a lower incidence of LBMD (OR:0.43; 95% CI: 0.21–0.88). Though the P for interaction was larger than 0.05.
This study found serum Vitamin E levels were negatively associated with LBMD in older Americans. Serum Vitamin E levels were positively associated with femur BMD in older Americans.</description><subject>Aged</subject><subject>blood serum</subject><subject>Bone Density</subject><subject>Bone Diseases, Metabolic - blood</subject><subject>Bone Diseases, Metabolic - epidemiology</subject><subject>Bone mineral density</subject><subject>clinical nutrition</subject><subject>Cross-Sectional Studies</subject><subject>Elderly</subject><subject>Female</subject><subject>Femur</subject><subject>Humans</subject><subject>lumbar spine</subject><subject>Lumbar Vertebrae</subject><subject>Male</subject><subject>Middle Aged</subject><subject>National Health and Nutrition Examination Survey</subject><subject>Nutrition Surveys</subject><subject>Osteopenia</subject><subject>Osteoporosis</subject><subject>Osteoporosis - blood</subject><subject>people</subject><subject>regression analysis</subject><subject>risk</subject><subject>Risk Factors</subject><subject>Vitamin E</subject><subject>Vitamin E - blood</subject><issn>2405-4577</issn><issn>2405-4577</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUcFqGzEQFaEhMY7_IAQde1lXWkkrq4eCCUkaMPSSnIVWmk3kyquttHbw30eOk5JTCwMzaN68h95D6JKSOSW0-bae29BDHuY1qfmclCLNCZrUnIiKCym_fJrP0SznNSHlTilOyRk6ZwspJRdkgp5W8QUSTj7_xrHDIb7gNvaAN76HZAJ20Gc_7rHv8bN_esY7P5qywzc4wA7C4T0GVxgGiEOA73iJbYo5Vxns6GNfKPK4dfsLdNqZkGH23qfo8fbm4fpntfp1d3-9XFWWcT5WsoFWMdp1zBnZtAvRKOs6uZCM09a0VLWypk451vHSaeuMkFbWhjRUEasYm6KvR94hxT9byKPe-GwhBNND3GbNqGCSU9k0_4cSoWohqBIFyo_Qt78l6PSQ_MakvaZEHwLRa30MRB8C0aQUOShcvSts2w24v0cf9hfAjyMAiiU7D0ln66G34Hwq_mkX_b8VXgFgnp1y</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Peng, Ying-Long</creator><creator>Wang, Zi-Yan</creator><creator>Wang, Xuan-Jia</creator><creator>Ji, Yu-Tong</creator><creator>Wen, Yaqing</creator><creator>Mai, Yanpei</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0009-0009-8924-985X</orcidid><orcidid>https://orcid.org/0000-0002-7162-4422</orcidid></search><sort><creationdate>202406</creationdate><title>Lower risk of low bone mineral density in high vitamin E level in older people: A cross-sectional study</title><author>Peng, Ying-Long ; Wang, Zi-Yan ; Wang, Xuan-Jia ; Ji, Yu-Tong ; Wen, Yaqing ; Mai, Yanpei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-76eb931ff3da76b8569cdf787341bab19b721d9d3f421d1bda57c72a06190c933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>blood serum</topic><topic>Bone Density</topic><topic>Bone Diseases, Metabolic - blood</topic><topic>Bone Diseases, Metabolic - epidemiology</topic><topic>Bone mineral density</topic><topic>clinical nutrition</topic><topic>Cross-Sectional Studies</topic><topic>Elderly</topic><topic>Female</topic><topic>Femur</topic><topic>Humans</topic><topic>lumbar spine</topic><topic>Lumbar Vertebrae</topic><topic>Male</topic><topic>Middle Aged</topic><topic>National Health and Nutrition Examination Survey</topic><topic>Nutrition Surveys</topic><topic>Osteopenia</topic><topic>Osteoporosis</topic><topic>Osteoporosis - blood</topic><topic>people</topic><topic>regression analysis</topic><topic>risk</topic><topic>Risk Factors</topic><topic>Vitamin E</topic><topic>Vitamin E - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peng, Ying-Long</creatorcontrib><creatorcontrib>Wang, Zi-Yan</creatorcontrib><creatorcontrib>Wang, Xuan-Jia</creatorcontrib><creatorcontrib>Ji, Yu-Tong</creatorcontrib><creatorcontrib>Wen, Yaqing</creatorcontrib><creatorcontrib>Mai, Yanpei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Clinical nutrition ESPEN</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peng, Ying-Long</au><au>Wang, Zi-Yan</au><au>Wang, Xuan-Jia</au><au>Ji, Yu-Tong</au><au>Wen, Yaqing</au><au>Mai, Yanpei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lower risk of low bone mineral density in high vitamin E level in older people: A cross-sectional study</atitle><jtitle>Clinical nutrition ESPEN</jtitle><addtitle>Clin Nutr ESPEN</addtitle><date>2024-06</date><risdate>2024</risdate><volume>61</volume><spage>316</spage><epage>321</epage><pages>316-321</pages><issn>2405-4577</issn><eissn>2405-4577</eissn><abstract>Osteoporosis and osteopenia, together known as low bone mineral density (LBMD), are common problems in the elderly. LBMD may cause fragility fractures in the elderly. The relationship between Vitamin E and LBMD in old Americans is still unclear. In this study, we investigated the relationship between serum Vitamin E levels and LBMD in the elderly.
We utilized data from the National Health and Nutrition Examination Survey (NHANES) 2017–2018 and ultimately included 378 participants aged 50 to 79. Multivariable logistic or linear regression models were applied to examine the associations between serum Vitamin E levels and LBMD, total femur or lumbar spine BMD after adjusting for covariates.
After adjusting for all covariates, higher serum Vitamin E levels reduced the risk of LBMD (OR 0.76; 95% CI 0.58–1.00) and were positively associated with total femur BMD (β: 0.02; 95% CI: 0.01–0.03)， after adjusting for all covariates. In the subgroup analysis, for the BMI normal group (BMI<25), the serum Vitamin E levels were positively associated with the total femur (β: 0.03; 95% CI: 0.01–0.05) and lumbar spine BMD (β: 0.04; 95% CI: 0.01–0.07). In the BMI normal group, people with high serum Vitamin E levels have a lower incidence of LBMD (OR:0.43; 95% CI: 0.21–0.88). Though the P for interaction was larger than 0.05.
This study found serum Vitamin E levels were negatively associated with LBMD in older Americans. Serum Vitamin E levels were positively associated with femur BMD in older Americans.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38777450</pmid><doi>10.1016/j.clnesp.2024.04.006</doi><tpages>6</tpages><orcidid>https://orcid.org/0009-0009-8924-985X</orcidid><orcidid>https://orcid.org/0000-0002-7162-4422</orcidid></addata></record> |
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| subjects | Aged blood serum Bone Density Bone Diseases, Metabolic - blood Bone Diseases, Metabolic - epidemiology Bone mineral density clinical nutrition Cross-Sectional Studies Elderly Female Femur Humans lumbar spine Lumbar Vertebrae Male Middle Aged National Health and Nutrition Examination Survey Nutrition Surveys Osteopenia Osteoporosis Osteoporosis - blood people regression analysis risk Risk Factors Vitamin E Vitamin E - blood |
| title | Lower risk of low bone mineral density in high vitamin E level in older people: A cross-sectional study |
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