Lower risk of low bone mineral density in high vitamin E level in older people: A cross-sectional study

Osteoporosis and osteopenia, together known as low bone mineral density (LBMD), are common problems in the elderly. LBMD may cause fragility fractures in the elderly. The relationship between Vitamin E and LBMD in old Americans is still unclear. In this study, we investigated the relationship between serum Vitamin E levels and LBMD in the elderly. We utilized data from the National Health and Nutrition Examination Survey (NHANES) 2017–2018 and ultimately included 378 participants aged 50 to 79. Multivariable logistic or linear regression models were applied to examine the associations between serum Vitamin E levels and LBMD, total femur or lumbar spine BMD after adjusting for covariates. After adjusting for all covariates, higher serum Vitamin E levels reduced the risk of LBMD (OR 0.76; 95% CI 0.58–1.00) and were positively associated with total femur BMD (β: 0.02; 95% CI: 0.01–0.03)， after adjusting for all covariates. In the subgroup analysis, for the BMI normal group (BMI