Fast freezing inhibits melanin synthesis of melanocytes by modulating the Wnt/β‐catenin signalling pathway

Skin hyperpigmentation is mainly caused by excessive synthesis of melanin; however, there is still no safe and effective therapy for its removal. Here, we found that the dermal freezer was able to improve UVB‐induced hyperpigmentation of guinea pigs without causing obvious epidermal damage. We also...

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Veröffentlicht in:	Experimental dermatology 2024-05, Vol.33 (5), p.e15101-n/a
Hauptverfasser:	Wu, Siyun, Yuan, Xinyue, Tang, Zexin, Zang, Kai, Wang, Caibing, Li, Zhiyi, Li, Huangde, Ye, Xiyun, Dang, Yongyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis beta Catenin - metabolism Catenin Cell Survival Cell viability fast freezing Freezing Gene expression Glycogen Synthase Kinase 3 beta - metabolism Guinea Pigs Hyperpigmentation Hyperpigmentation - metabolism Interferon Type I Intramolecular Oxidoreductases - metabolism Melanin melanin synthesis Melanins - biosynthesis Melanins - metabolism Melanocytes Melanocytes - metabolism Mice Microphthalmia-Associated Transcription Factor - metabolism MITF Monophenol Monooxygenase - metabolism Oxidoreductases - metabolism Pregnancy Proteins Signal transduction Skin tyrosinase Ultraviolet Rays Wnt protein Wnt Signaling Pathway Wnt/β‐catenin
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Zusammenfassung:	Skin hyperpigmentation is mainly caused by excessive synthesis of melanin; however, there is still no safe and effective therapy for its removal. Here, we found that the dermal freezer was able to improve UVB‐induced hyperpigmentation of guinea pigs without causing obvious epidermal damage. We also mimic freezing stimulation at the cellular level by rapid freezing and observed that freezing treatments
ISSN:	0906-6705 1600-0625 1600-0625
DOI:	10.1111/exd.15101