The genetics and clinical outcomes in 151 cases of fetal growth restriction: A Chinese single-center study

•SNP array has application value in fetuses with intrauterine growth restriction.•The positive detection rate of FGR combined with structural deformity was significantly higher than that of isolated FGR group.•The positive detection rate of FGR with structural malformations was significantly higher...

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Veröffentlicht in:European journal of obstetrics & gynecology and reproductive biology 2024-07, Vol.298, p.128-134
Hauptverfasser: Peng, Can, Hu, LanPing, Bu, XiuFen, Li, HongYu, Jiang, XuanYu, Zhou, ShiHao, Deng, Li, He, Jun, LinPeng, SiYuan
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Sprache:eng
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Zusammenfassung:•SNP array has application value in fetuses with intrauterine growth restriction.•The positive detection rate of FGR combined with structural deformity was significantly higher than that of isolated FGR group.•The positive detection rate of FGR with structural malformations was significantly higher than that with non-structural malformations.•The positive detection rate of FGR with structural malformations was significantly higher than that with non-structural malformations. To determine the detection rate of chromosomal abnormalities and pregnancy outcomes in fetuses with intrauterine growth restriction. Study design A total of 151 fetal samples with intrauterine growth restriction were divided into the isolated fetal growth restriction (FGR) group, FGR group with structural malformation, and FGR group with non-structural malformation, according to ultrasound abnormalities. The enrolled patients were divided into an early onset FGR group (
ISSN:0301-2115
1872-7654
1872-7654
DOI:10.1016/j.ejogrb.2024.05.004