Immunity by AS03ation: The natural adjuvantage

Humans do not respond equally to vaccination. To investigate why, Mulè et al. developed a multimodal framework and found that high responders after unadjuvanted influenza vaccination exist in a naturally adjuvanted state, mimicking innate immunophenotypes following AS03-adjuvanted vaccination. This...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2024-05, Vol.57 (5), p.927-929
Hauptverfasser:	Hansen, Lena, Guthmiller, Jenna J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Adjuvants, Vaccine Animals Antibodies, Viral - immunology Humans Immunity, Humoral Immunity, Innate - immunology Influenza Vaccines - immunology Influenza, Human - immunology Influenza, Human - prevention & control Vaccination
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Zusammenfassung:	Humans do not respond equally to vaccination. To investigate why, Mulè et al. developed a multimodal framework and found that high responders after unadjuvanted influenza vaccination exist in a naturally adjuvanted state, mimicking innate immunophenotypes following AS03-adjuvanted vaccination. This highlights biological factors that set apart high-antibody responders and how adjuvants can boost innate immune cues to improve humoral immunity. Humans do not respond equally to vaccination. To investigate why, Mulè et al. developed a multimodal framework and found that high responders after unadjuvanted influenza vaccination exist in a naturally adjuvanted state, mimicking innate immunophenotypes following AS03-adjuvanted vaccination. This highlights biological factors that set apart high-antibody responders and how adjuvants can boost innate immune cues to improve humoral immunity.
ISSN:	1074-7613 1097-4180
DOI:	10.1016/j.immuni.2024.04.011