Chemically Powered Nanomotors with Magnetically Responsive Function for Targeted Delivery of Exosomes

Janus structure plays a crucial role in achieving chemically driven nanomotors with exceptional motion performance. However, Janus‐structured chemically driven nanomotors with magnetic responsiveness are commonly fabricated by sputtering metal films. In the study, a self‐assembly technique is employed to asymmetrically modify the surfaces of magnetic silica (SiO2@Fe3O4) nanoparticles with platinum nanoparticles, resulting in the formation of this kind nanomotors. Compared to platinum film, platinum nanoparticles exhibit a larger surface area and a higher catalytic activity. Hence, the nanomotors demonstrate improved diffusion capabilities at a significantly lower concentration (0.05%) of hydrogen peroxide (H2O2). Meanwhile, exosomes have gained attention as a potential tool for the efficient delivery of biological therapeutic drugs due to their biocompatibility. However, the clinical applications of exosomes are limited by their restricted tropism. The previously obtained nanomotors are utilized to deliver exosomes, greatly enhancing its targetability. The drug doxorubicin (DOX) is subsequently encapsulated within exosomes, acting as a representative drug model. Under the conditions of H2O2 concentration at the tumor site, the exosomes exhibited a significantly enhanced rate of entry into the breast cancer cells. The utilization of the nanomotors for exosomes presents a novel approach in the development of hybrid chemically and magnetically responsive nanomotors. A self‐assembly technique is employed to modify the surfaces of magnetic silica (SiO2@Fe3O4) nanoparticles with platinum (Pt) nanoparticles, resulting in the formation of Janus‐structured chemically powered nanomotors with magnetically responsive function. The catalase‐like activity of nanomotors is more than twice that of conventional nanomotors using Pt film. Then, the nanomotors are utilized to deliver exosomes, greatly enhancing the targetability to tumor cells.