Activin A: a marker of mineral bone disorder in children with chronic kidney disease?

Background Activin A has been shown to enhance osteoclast activity and its inhibition results in bone growth. The potential role of activin A as a marker of chronic kidney disease-mineral bone disease (CKD-MBD) and its relationship with other markers has not been studied in children with CKD. Method...

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Veröffentlicht in:	Pediatric nephrology (Berlin, West) West), 2024-09, Vol.39 (9), p.2773-2777
Hauptverfasser:	Shankar, Raagul, Saha, Abhijeet, Dhull, Rachita Singh, Shroff, Rukshana, Nangia, Anita, Sharma, Sunita
Format:	Artikel
Sprache:	eng
Schlagworte:	Activin Activins - blood Adolescent Alkaline phosphatase Alkaline Phosphatase - blood Biomarkers - blood Bone diseases Bone Diseases, Metabolic - blood Bone Diseases, Metabolic - diagnosis Bone Diseases, Metabolic - etiology Bone growth Calcium - blood Case-Control Studies Cathepsin K Cathepsin K - blood Child Child, Preschool Children Chronic Kidney Disease-Mineral and Bone Disorder - blood Chronic Kidney Disease-Mineral and Bone Disorder - diagnosis Chronic Kidney Disease-Mineral and Bone Disorder - etiology Creatinine Cross-Sectional Studies Female Fibroblast growth factor 23 Fibroblast Growth Factor-23 - blood Fibroblast Growth Factors - blood Humans Kidney diseases Male Medicine Medicine & Public Health Minerals Nephrology Original Article Parathyroid hormone Parathyroid Hormone - blood Pediatrics Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - complications Urology What’s New in Chronic Kidney Disease
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Zusammenfassung:	Background Activin A has been shown to enhance osteoclast activity and its inhibition results in bone growth. The potential role of activin A as a marker of chronic kidney disease-mineral bone disease (CKD-MBD) and its relationship with other markers has not been studied in children with CKD. Methods A cross sectional study was conducted among 40 children aged 2 to 18 years with CKD (Stage 2 to 5; 10 in each stage) and 40 matched controls. Activin A, cathepsin K, FGF-23, PTH, serum calcium, phosphorous and alkaline phosphatase in both groups were measured and compared. The correlation of activin A and markers of CKD-MBD was studied. A p value of
ISSN:	0931-041X 1432-198X 1432-198X
DOI:	10.1007/s00467-024-06400-x