Obstructive sleep apnea in children with cystic fibrosis on highly effective modulator therapy

Obstructive sleep apnea in children with cystic fibrosis on highly effective modulator therapy

Introduction Obstructive sleep apnea (OSA) is common in children with cystic fibrosis (CF). Highly effective modulator therapies (HEMT) have led to improved sinopulmonary disease, but whether this translates to a lower frequency of OSA is unknown. Methods We conducted a single center retrospective r...

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Veröffentlicht in:Pediatric pulmonology 2024-10, Vol.59 (10), p.2535-2542
Hauptverfasser: Shakkottai, Aarti, Kim, Stephany, Mitchell, Ron B.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
adolescents
Child
Child, Preschool
children
Cystic fibrosis
Cystic Fibrosis - complications
Cystic Fibrosis - physiopathology
Female
Humans
Infant
Male
Nutritional status
obstructive sleep apnea
Polysomnography
Retrospective Studies
Sleep apnea
Sleep Apnea, Obstructive - complications
Sleep Apnea, Obstructive - epidemiology
Sleep Apnea, Obstructive - therapy
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Zusammenfassung:Introduction Obstructive sleep apnea (OSA) is common in children with cystic fibrosis (CF). Highly effective modulator therapies (HEMT) have led to improved sinopulmonary disease, but whether this translates to a lower frequency of OSA is unknown. Methods We conducted a single center retrospective review of polysomnographic (PSG) data from 2012 to 2023 in patients aged 0–18 years with CF to assess frequency of OSA. Participants were classified based on HEMT status. Logistic regression was used to quantify the association between HEMT and OSA with p 
ISSN:8755-6863
1099-0496
1099-0496
DOI:10.1002/ppul.27061