Organellophagy regulates cell death:A potential therapeutic target for inflammatory diseases

[Display omitted] •Cell death is the main culprit of inflammatory diseases.•Dysregulated alterations in organelle structure and function lead to cell death.•Organellophagy sustains the functional stability of organelles.•Organellophagy orchestrates celluar homeostasis and viability via delicate regulation of cell death.•Organellophagy could be a therapeutic target for inflammatory diseases. Dysregulated alterations in organelle structure and function have a significant connection with cell death, as well as the occurrence and development of inflammatory diseases. Maintaining cell viability and inhibiting the release of inflammatory cytokines are essential measures to treat inflammatory diseases. Recently, many studies have showed that autophagy selectively targets dysfunctional organelles, thereby sustaining the functional stability of organelles, alleviating the release of multiple cytokines, and maintaining organismal homeostasis. Organellophagy dysfunction is critically engaged in different kinds of cell death and inflammatory diseases. We summarized the current knowledge of organellophagy (e.g., mitophagy, reticulophagy, golgiphagy, lysophagy, pexophagy, nucleophagy, and ribophagy) and the underlying mechanisms by which organellophagy regulates cell death. We outlined the potential role of organellophagy in the modulation of cell fate during the inflammatory response to develop an intervention strategy for the organelle quality control in inflammatory diseases.