Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction

We performed genome-wide association studies of breast cancer including 18,034 cases and 22,104 controls of African ancestry. Genetic variants at 12 loci were associated with breast cancer risk ( P

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Bibliographische Detailangaben
Veröffentlicht in:	Nature genetics 2024-05, Vol.56 (5), p.819-826
Hauptverfasser:	Jia, Guochong, Ping, Jie, Guo, Xingyi, Yang, Yaohua, Tao, Ran, Li, Bingshan, Ambs, Stefan, Barnard, Mollie E., Chen, Yu, Garcia-Closas, Montserrat, Gu, Jian, Hu, Jennifer J., Huo, Dezheng, John, Esther M., Li, Christopher I., Li, James L., Nathanson, Katherine L., Nemesure, Barbara, Olopade, Olufunmilayo I., Pal, Tuya, Press, Michael F., Sanderson, Maureen, Sandler, Dale P., Shu, Xiao-Ou, Troester, Melissa A., Yao, Song, Adejumo, Prisca O., Ahearn, Thomas, Brewster, Abenaa M., Hennis, Anselm J. M., Makumbi, Timothy, Ndom, Paul, O’Brien, Katie M., Olshan, Andrew F., Oluwasanu, Mojisola M., Reid, Sonya, Butler, Ebonee N., Huang, Maosheng, Ntekim, Atara, Qian, Huijun, Zhang, Haoyu, Ambrosone, Christine B., Cai, Qiuyin, Long, Jirong, Palmer, Julie R., Haiman, Christopher A., Zheng, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	692/308/174 692/699/67/1347 Agriculture Alleles Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Black People - genetics Breast cancer Breast Neoplasms - genetics Cancer Research Case-Control Studies Chromosome 2 Datasets Female Females Gene Function Genetic diversity Genetic Loci Genetic Predisposition to Disease Genetic variance Genome-wide association studies Genome-Wide Association Study - methods Genomes Health risks Hispanic Americans Human Genetics Humans Middle Aged Multifactorial Inheritance - genetics Polygenic inheritance Polymorphism, Single Nucleotide Population genetics Population studies Predictions Risk Risk Factors Triple Negative Breast Neoplasms - genetics White People - genetics
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Beschreibung
Zusammenfassung:	We performed genome-wide association studies of breast cancer including 18,034 cases and 22,104 controls of African ancestry. Genetic variants at 12 loci were associated with breast cancer risk ( P
ISSN:	1061-4036 1546-1718 1546-1718
DOI:	10.1038/s41588-024-01736-4