Hearing abnormalities in patients treated with teprotumumab

Hearing abnormalities in patients treated with teprotumumab

The introduction of teprotumumab for the treatment of thyroid eye disease has dramatically improved management of this life-changing condition; however, clinical trials and experience in the clinic have revealed associated hearing abnormalities.

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Bibliographische Detailangaben
Veröffentlicht in:Nature reviews. Endocrinology 2024-07, Vol.20 (7), p.381-382
Hauptverfasser: Brant, Jason A., Kikkawa, Don O., Smith, Terry J.
Format: Artikel
Sprache:eng
Schlagworte:
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Antibodies, Monoclonal, Humanized - adverse effects
Antibodies, Monoclonal, Humanized - therapeutic use
Audiometry
Clinical trials
Comment
Diplopia
Endocrinology
Eye diseases
Fibroblasts
Hair
Hearing Disorders - chemically induced
Hearing Disorders - epidemiology
Hearing loss
Hearing Loss - chemically induced
Hearing protection
Humans
Inflammation
Insulin-like growth factors
Kinases
Medicine
Medicine & Public Health
Otology
Pathogenesis
Quality of life
Risk factors
Steroids
Thyroid gland
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Beschreibung
Zusammenfassung:The introduction of teprotumumab for the treatment of thyroid eye disease has dramatically improved management of this life-changing condition; however, clinical trials and experience in the clinic have revealed associated hearing abnormalities.
ISSN:1759-5029
1759-5037
1759-5037
DOI:10.1038/s41574-024-00995-9