Designing boosting immunogens for HIV-1 vaccine development

Inducing HIV-1 broadly neutralizing antibodies (bnAbs) through vaccination poses exceptional challenges. In this issue of Cell Host & Microbe, Wiehe and colleagues report the elicitation of affinity-matured bnAbs in knock-in mice through boosting immunogen vaccination, which selects for key impr...

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Veröffentlicht in:	Cell host & microbe 2024-05, Vol.32 (5), p.632-634
1. Verfasser:	Liu, Qingbo
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Vaccines - genetics AIDS Vaccines - immunology Animals Antibodies, Neutralizing - immunology Gene Knock-In Techniques HIV Antibodies - immunology HIV Infections - immunology HIV Infections - prevention & control HIV-1 - genetics HIV-1 - immunology Humans Immunization, Secondary Mice Vaccination Vaccine Development
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Zusammenfassung:	Inducing HIV-1 broadly neutralizing antibodies (bnAbs) through vaccination poses exceptional challenges. In this issue of Cell Host & Microbe, Wiehe and colleagues report the elicitation of affinity-matured bnAbs in knock-in mice through boosting immunogen vaccination, which selects for key improbable mutations. Inducing HIV-1 broadly neutralizing antibodies (bnAbs) through vaccination poses exceptional challenges. In this issue of Cell Host & Microbe, Wiehe and colleagues report the elicitation of affinity-matured bnAbs in knock-in mice through boosting immunogen vaccination, which selects for key improbable mutations.
ISSN:	1931-3128 1934-6069
DOI:	10.1016/j.chom.2024.04.008