Actinomycosis presenting as a nasopharyngeal mass: A case report

•In this work,we evaluated actinomycosis is a rare saprophytic infection characterized by a slow progression, leading to the development of granulomatous and suppurative lesions.•This condition is caused by actinomycetes, which are part of the resident oral microbiome.•The symptoms and signs of actinomycosis are atypical and rarely manifest in the nasopharynx.•Consequently, it can be challenging to distinguish actinomycosis from nasopharyngeal carcinoma, making diagnosis difficult.•Histopathology is usually relied upon for diagnosis, although culture may pose challenges. Fortunately, actinomycetes are highly sensitive to penicillin.•Therefore, timely treatment with high doses of penicillin is crucial for successful recovery.•In this case study, we present the details of a 53-year-old female patient with no history of mucosal damage or tooth decay but with a previous partial thyroidectomy.•The patient experienced recurring neck pain accompanied by progressive limitation of neck movement.•Nasopharyngoscopy revealed the presence of a smooth-surfaced mass.•Subsequent biopsy, clinical imaging, microbiological analysis, and histological findings confirmed the diagnosis of actinomycosis.Following a comprehensive treatment plan involving a combination of penicillin and doxycycline for a duration of two months, the disease was successfully eradicated.I hope this paper is suitable for “Oral Oncology”. Actinomycetes are predominantly pathogenic bacteria that lack aerial hyphae and do not form spores. They are generally anaerobic or facultative anaerobic Gram-positive bacteria, belonging to the prokaryotic group. Actinomycetes are widely distributed in nature, similar to other bacteria, and are mostly saprophytic, with a few being parasitic. They are named as such due to their colony's radial form. The symptoms and signs of actinomycosis are atypical and rarely manifest in the nasopharynx. Consequently, it can be challenging to distinguish actinomycosis from nasopharyngeal carcinoma, making diagnosis difficult. Histopathology is usually relied upon for diagnosis, although culture may pose challenges. Fortunately, actinomycetes are highly sensitive to penicillin. Therefore, timely treatment with high doses of penicillin is crucial for successful recovery. In this case study, we present the details of a 53-year-old female patient with no history of mucosal damage or tooth decay but with a previous partial thyroidectomy. The patient experienced recurring neck pain accomp