Postintensive care syndrome in patients and family members. Analysis of COVID-19 and non-COVID-19 cohorts, with face-to-face follow-up at three months and one year

Compare prevalence and profile of post-intensive care patient (P-PICS) and family/caregiver (F-PICS) syndrome in two cohorts (COVID and non-COVID) and analyse risk factors for P-PICS. Prospective, observational cohort (March 2018–2023), follow-up at three months and one year. 14-bed polyvalent Intensive Care Unit (ICU), Level II Hospital. 265 patients and 209 relatives. Inclusion criteria patients: age > 18 years, mechanical ventilation > 48 h, ICU stay > 5 days, delirium, septic shock, acute respiratory distress syndrome, cardiac arrest. Inclusion criteria family: those who attended. Follow-up 3 months and 1 year after hospital discharge. Patients: sociodemographic, clinical, evolutive, physical, psychological and cognitive alterations, dependency degree and quality of life. Main caregivers: mental state and physical overload. 64.9% PICS-P, no differences between groups. COVID patients more physical alterations than non-COVID (P = .028). These more functional deterioration (P = .005), poorer quality of life (P = .003), higher nutritional alterations (P = .004) and cognitive deterioration (P < .001). 19.1% PICS-F, more frequent in relatives of non-COVID patients (17.6% vs. 5.5%; P = .013). Independent predictors of PICS-P: first years of the study (OR: 0.484), higher comorbidity (OR: 1.158), delirium (OR: 2.935), several reasons for being included (OR: 3.171) and midazolam (OR: 4.265). Prevalence PICS-P and PICS-F between both cohorts was similar. Main factors associated with the development of SPCI-P were: higher comorbidity, delirium, midazolan, inclusion for more than one reason and during the first years. Comparar prevalencia y características del síndrome post-cuidados intensivos paciente (SPCI-P) y familiar/cuidador (SPCI-F) en dos cohortes (COVID y no COVID) y analizar factores riesgo de SPCI-P. Prospectivo, observacional cohortes (Marzo 2018–2023), seguimiento a tres meses y año. Unidad de Cuidados Intensivos (UCI) polivalente 14 camas, Hospital Nivel II. Pacientes: 265, familiares: 209. Criterios inclusión pacientes: edad > 18 años, ventilación mecánica > 48 horas, estancia UCI > 5 días, delirium, shock séptico, síndrome distrés respiratorio agudo, parada cardiaca. Criterios inclusión familiares: acudir consulta. Seguimiento 3 meses y año del alta hospitalaria. Pacientes: sociodemográficas, clínicas, evolutivas, alteraciones físicas, psíquicas y cognitivas, dependencia y calidad de vida. Familiares: estado mental y sobrecarga física. SPCI-P 64,9%,