Enzyme-Driven LC–HRMS Approach for Specific Recognition of 12α-Hydroxy Bile Acids

The synthesis of 12α-hydroxylated bile acids (12HBAs) and non-12α-hydroxylated bile acids (non-12HBAs) occurs via classical and alternative pathways, respectively. The composition of these BAs is a crucial index for pathophysiologic assessment. However, accurately differentiating 12HBAs and non-12HB...

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Veröffentlicht in:	Analytical chemistry (Washington) 2024-05, Vol.96 (21), p.8613-8621
Hauptverfasser:	Zhao, An-Qi, Zheng, Jia-Yi, Chen, Chen, Liu, Li-Fang, Xin, Gui-Zhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Bile acids Bile Acids and Salts - analysis Bile Acids and Salts - chemistry Bile Acids and Salts - metabolism Biological effects Chromatography, Liquid E coli Enzymes Escherichia coli - enzymology Escherichia coli - metabolism Explicit knowledge Heterogeneity Humans Hydroxysteroids Liquid chromatography Mass Spectrometry Mass spectroscopy Mice Pattern recognition Synthesis
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