Prognostic value and association of the age-adjusted Charlson Comorbidity Index with sarcopenia within patients with gastric cancer after radical resection

The association between the age-adjusted Charlson Comorbidity Index (ACCI) and sarcopenia in patients with gastric cancer (GC) remains ambiguous. This study aimed to investigate the association between the ACCI and sarcopenia and the prognostic value in patients with GC after radical resection. In a...

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Veröffentlicht in:Journal of gastrointestinal surgery 2024-07, Vol.28 (7), p.1089-1094
Hauptverfasser: Shao, Jiancan, Gao, Zekan, Shen, Qingzheng, Zhi, Huaiqing, Wang, Xiang, Zheng, Jingwei, Chen, Yajin, Shi, Ang, Wu, Dongze, Cai, Wanda, Chen, Xiaodong, Shen, Xian
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Sprache:eng
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Zusammenfassung:The association between the age-adjusted Charlson Comorbidity Index (ACCI) and sarcopenia in patients with gastric cancer (GC) remains ambiguous. This study aimed to investigate the association between the ACCI and sarcopenia and the prognostic value in patients with GC after radical resection. In addition, this study aimed to develop a novel prognostic scoring system based on these factors. Univariate and multivariate Cox regression analyses were used to determine prognostic factors in patients undergoing radical GC resection. Based on the ACCI and sarcopenia, a new prognostic score (age-adjusted Charlson Comorbidity Index and Sarcopenia [ACCIS]) was established, and its prognostic value was assessed. This study included 1068 patients with GC. Multivariate analysis revealed that the ACCI and sarcopenia were independent risk factors during the prognosis of GC (P = 0.001 and P 
ISSN:1091-255X
1873-4626
1873-4626
DOI:10.1016/j.gassur.2024.04.027