Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis

In a recent publication in Nature, Xu et al.1 discovered a role of CRL5-SPSB3 ubiquitin ligase in promoting ubiquitination and degradation of nuclear cGAS, which prevents aberrant cGAS activation by genomic DNA and contributes to the maintenance of immune homeostasis. In a recent publication in Natu...

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Veröffentlicht in:	Molecular cell 2024-05, Vol.84 (9), p.1635-1636
1. Verfasser:	Chen, Ruey-Hwa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Nucleus - metabolism Homeostasis Humans Nucleotidyltransferases - genetics Nucleotidyltransferases - metabolism Proteolysis Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination
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