Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis
In a recent publication in Nature, Xu et al.1 discovered a role of CRL5-SPSB3 ubiquitin ligase in promoting ubiquitination and degradation of nuclear cGAS, which prevents aberrant cGAS activation by genomic DNA and contributes to the maintenance of immune homeostasis. In a recent publication in Natu...
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Veröffentlicht in: | Molecular cell 2024-05, Vol.84 (9), p.1635-1636 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | In a recent publication in Nature, Xu et al.1 discovered a role of CRL5-SPSB3 ubiquitin ligase in promoting ubiquitination and degradation of nuclear cGAS, which prevents aberrant cGAS activation by genomic DNA and contributes to the maintenance of immune homeostasis.
In a recent publication in Nature, Xu et al. discovered a role of CRL5-SPSB3 ubiquitin ligase in promoting ubiquitination and degradation of nuclear cGAS, which prevents aberrant cGAS activation by genomic DNA and contributes to the maintenance of immune homeostasis. |
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ISSN: | 1097-2765 1097-4164 |
DOI: | 10.1016/j.molcel.2024.04.003 |