Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis
In a recent publication in Nature, Xu et al.1 discovered a role of CRL5-SPSB3 ubiquitin ligase in promoting ubiquitination and degradation of nuclear cGAS, which prevents aberrant cGAS activation by genomic DNA and contributes to the maintenance of immune homeostasis. In a recent publication in Natu...
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| Veröffentlicht in: | Molecular cell 2024-05, Vol.84 (9), p.1635-1636 |
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| container_title | Molecular cell |
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| creator | Chen, Ruey-Hwa |
| description | In a recent publication in Nature, Xu et al.1 discovered a role of CRL5-SPSB3 ubiquitin ligase in promoting ubiquitination and degradation of nuclear cGAS, which prevents aberrant cGAS activation by genomic DNA and contributes to the maintenance of immune homeostasis.
In a recent publication in Nature, Xu et al. discovered a role of CRL5-SPSB3 ubiquitin ligase in promoting ubiquitination and degradation of nuclear cGAS, which prevents aberrant cGAS activation by genomic DNA and contributes to the maintenance of immune homeostasis. |
| doi_str_mv | 10.1016/j.molcel.2024.04.003 |
| format | Article |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Cell Nucleus - metabolism Homeostasis Humans Nucleotidyltransferases - genetics Nucleotidyltransferases - metabolism Proteolysis Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination |
| title | Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis |
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