Palladium-Catalyzed Arylation of C(sp2)–H Bonds and C(sp3)–H Bonds with 4‑Amino-benzotriazole as the Bidentate Directing Group

The arylation of C­(sp2)–H and C­(sp3)–H bonds in carboxylic acids catalyzed by Pd­(II) with 4-aminobentriazole as the directing group was investigated. In addition to activation of the C­(sp2)–H bond, selective arylation of alkyl carboxylic acids and amino acids in the β position can also be achieved. This strategy involved a 5,5-bicyclic Pd intermediate complex whose structure was determined by X-ray single crystal diffraction analysis. Importantly, the DG (directing group) can be easily removed under mild conditions.