Evaluation of the prognostic impact of pathologic tumor regression grade on patients with colorectal cancer after preoperative chemoradiotherapy
Background The prognostic value of the pathological response to preoperative chemoradiotherapy (CRT) in rectal cancer (RC) remains unknown. Objectives We aimed to assess the predictive value of the response to CRT that was derived from an evaluation of the histological findings (whole‐section vs. re...
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Veröffentlicht in: | Journal of surgical oncology 2024-06, Vol.129 (8), p.1521-1533 |
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Hauptverfasser: | , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Background
The prognostic value of the pathological response to preoperative chemoradiotherapy (CRT) in rectal cancer (RC) remains unknown.
Objectives
We aimed to assess the predictive value of the response to CRT that was derived from an evaluation of the histological findings (whole‐section vs. representative‐section sampling) and attempted to determine an objective cut‐off value for the tumor regression grade (TRG).
Methods
We examined the association of the TRG with the outcomes (recurrence‐free survival [RFS] and overall survival [OS]) of 78 patients with RC. Patients with RC treated with preoperative CRT were divided into development (30 cases) and validation (48 cases) cohorts. The TRG was classified as grades I (Ia, Ib), II, and III. The cut‐off value was determined by receiver operating characteristic (ROC) curve analysis.
Results
The TRG determined from whole‐section sampling versus representative‐section sampling was more strongly correlated with patient survival. We found that in both cohorts, patients with a cut‐off value of |
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ISSN: | 0022-4790 1096-9098 1096-9098 |
DOI: | 10.1002/jso.27662 |