Immune profiling reveals umbilical cord blood mononuclear cells from South India display an IL-8 dominant, CXCL-10 deficient polyfunctional monocyte response to pathogen-associated molecular patterns that is distinct from adult blood cells

Neonate responses to pathogen-associated molecular patterns (PAMPS) differ from adults; such understanding is poor in Indian neonates, despite recognized significant infectious risk. Immune profiling analysis was undertaken of 10 secreted mediators contextualized with cellular source induced by six...

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Veröffentlicht in:	Clinical and experimental immunology 2024-08, Vol.217 (3), p.263-278
Hauptverfasser:	Adiga, Vasista, Bindhu, Hima, Ahmed, Asma, Chetan Kumar, Nirutha, Tripathi, Himanshu, D'Souza, George, Dias, Mary, Shivalingaiah, Sudarshan, Rao, Srishti, K N, Shanti, Hawrylowicz, Catherine, Dwarkanath, Pratibha, Vyakarnam, Annapurna
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Candida albicans - immunology Chemokine CXCL10 - immunology COVID-19 - immunology Cytokines - metabolism Female Fetal Blood - immunology Humans India Infant, Newborn Interleukin-10 Interleukin-8 - immunology Leukocytes, Mononuclear - immunology Male Monocytes - immunology Poly I-C - immunology SARS-CoV-2 - immunology
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Zusammenfassung:	Neonate responses to pathogen-associated molecular patterns (PAMPS) differ from adults; such understanding is poor in Indian neonates, despite recognized significant infectious risk. Immune profiling analysis was undertaken of 10 secreted mediators contextualized with cellular source induced by six PAMPs in umbilical cord (CB; n = 21) and adult-blood (PBMC; n = 14) from a tertiary care hospital in South India. Differential cytokine expression analysis (minimum log2-fold difference; adj P-value
ISSN:	0009-9104 1365-2249 1365-2249
DOI:	10.1093/cei/uxae034