Role of magnetic resonance imaging in the prediction of histological grade in soft tissue sarcomas

Background Soft tissue sarcomas are rare malignant tumors with significant heterogeneity. The importance of classifying histological grades is fundamental to defining the treatment approach. Objective To evaluate magnetic resonance imaging (MRI) in predicting the histological grade of soft tissue sarcomas. Methods A retrospective observational study included patients over 18 years undergoing MRI and primary tumor surgery at AC Camargo Cancer Center from January 2015 to June 2022. Two radiologists evaluated MRI criteria (size, margin definition, heterogeneity of the T2 signal, high‐intensity peritumoral signal on T2, and postperitumoral contrast), and a grading prediction score was calculated. χ2 and logistic regression analyses were conducted. Results Sixty‐eight patients were included (38 men; median: 48 years). Moreover, 52 high‐grade and 16 low‐grade tumors were observed. The MRI criteria associated with histological grade were peritumoral high‐intensity T2‐weighted signals (p