Association Between Muscle Growth and Transcription of a Mutant MSTN Gene in Olive Flounder (Paralichthys olivaceus)
Myostatin (MSTN, also known as growth differentiation factor-8 (GDF-8)), a member of the transforming growth factor β (TGF-β) superfamily, functions as a negative regulator of skeletal muscle development and growth. However, it is also expressed in a wide range of tissues in fish and thus may have m...
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| Veröffentlicht in: | Marine biotechnology (New York, N.Y.) N.Y.), 2024-06, Vol.26 (3), p.599-608 |
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| creator | Kim, Ju-Won Kim, Julan Cho, Ja Young Shin, Younhee Son, Hyojung Sathiyamoorthy, Subramaniyam Kim, Bo-Seong Kim, Young-Ok Kang, Byeong-chul Kong, Hee Jeong |
| description | Myostatin (MSTN, also known as growth differentiation factor-8 (GDF-8)), a member of the transforming growth factor β (TGF-β) superfamily, functions as a negative regulator of skeletal muscle development and growth. However, it is also expressed in a wide range of tissues in fish and thus may have more diverse roles in this group than in mammals. In this study, we assessed the genome-wide transcriptional expression pattern associated with the CRISPR/Cas9-mutated MSTN gene in the olive flounder (
Paralichthys olivaceus
) in association with changes in cell proliferation and transportation processes. There were no differences in the hepatosomatic index, and the growth of male and female fish increased in the F1 progeny of the MSTN mutants. Furthermore, the histopathological analysis showed that myostatin editing resulted in a 41.24% increase in back muscle growth and 46.92% increase in belly muscle growth in male flounder compared with normal flounder, and a 16.01% increase in back muscle growth and 14.26% increase in belly muscle growth in female flounder compared with normal flounder. This study demonstrates that editing of the myostatin gene enhances muscle growth in olive flounder, with a notably more pronounced effect observed in males. Consequently, myostatin-edited male flounder could represent a valuable asset for the flounder aquaculture industry. |
| doi_str_mv | 10.1007/s10126-024-10322-y |
| format | Article |
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Paralichthys olivaceus
) in association with changes in cell proliferation and transportation processes. There were no differences in the hepatosomatic index, and the growth of male and female fish increased in the F1 progeny of the MSTN mutants. Furthermore, the histopathological analysis showed that myostatin editing resulted in a 41.24% increase in back muscle growth and 46.92% increase in belly muscle growth in male flounder compared with normal flounder, and a 16.01% increase in back muscle growth and 14.26% increase in belly muscle growth in female flounder compared with normal flounder. This study demonstrates that editing of the myostatin gene enhances muscle growth in olive flounder, with a notably more pronounced effect observed in males. Consequently, myostatin-edited male flounder could represent a valuable asset for the flounder aquaculture industry.</description><identifier>ISSN: 1436-2228</identifier><identifier>ISSN: 1436-2236</identifier><identifier>EISSN: 1436-2236</identifier><identifier>DOI: 10.1007/s10126-024-10322-y</identifier><identifier>PMID: 38683458</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animal tissues ; Animals ; Aquaculture ; Biomedical and Life Sciences ; Biotechnology ; Cell proliferation ; CRISPR ; CRISPR-Cas Systems ; Editing ; Engineering ; Female ; Females ; Fish ; Fish Proteins - genetics ; Fish Proteins - metabolism ; Fisheries ; Fishing ; Flounder ; Flounder - genetics ; Flounder - growth & development ; Flounder - metabolism ; Freshwater & Marine Ecology ; Gene Editing ; Gene expression ; Genes ; Genomes ; Growth factors ; Histopathology ; Life Sciences ; Male ; Males ; Marine fishes ; Microbiology ; MSTN gene ; Muscle Development - genetics ; Muscle, Skeletal - growth & development ; Muscle, Skeletal - metabolism ; Muscles ; Musculoskeletal system ; Mutants ; Mutation ; Myostatin ; Myostatin - genetics ; Myostatin - metabolism ; Offspring ; Paralichthys olivaceus ; Progeny ; R&D ; Radio frequency identification ; Research & development ; Science ; Seafood ; Seawater ; Skeletal muscle ; Transforming growth factor-b ; Zoology</subject><ispartof>Marine biotechnology (New York, N.Y.), 2024-06, Vol.26 (3), p.599-608</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-700a72413388d9ebd76bff1d4242bf4238de6fe1ede7442c74dcaebbf8b6d8dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10126-024-10322-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10126-024-10322-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38683458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Ju-Won</creatorcontrib><creatorcontrib>Kim, Julan</creatorcontrib><creatorcontrib>Cho, Ja Young</creatorcontrib><creatorcontrib>Shin, Younhee</creatorcontrib><creatorcontrib>Son, Hyojung</creatorcontrib><creatorcontrib>Sathiyamoorthy, Subramaniyam</creatorcontrib><creatorcontrib>Kim, Bo-Seong</creatorcontrib><creatorcontrib>Kim, Young-Ok</creatorcontrib><creatorcontrib>Kang, Byeong-chul</creatorcontrib><creatorcontrib>Kong, Hee Jeong</creatorcontrib><title>Association Between Muscle Growth and Transcription of a Mutant MSTN Gene in Olive Flounder (Paralichthys olivaceus)</title><title>Marine biotechnology (New York, N.Y.)</title><addtitle>Mar Biotechnol</addtitle><addtitle>Mar Biotechnol (NY)</addtitle><description>Myostatin (MSTN, also known as growth differentiation factor-8 (GDF-8)), a member of the transforming growth factor β (TGF-β) superfamily, functions as a negative regulator of skeletal muscle development and growth. However, it is also expressed in a wide range of tissues in fish and thus may have more diverse roles in this group than in mammals. In this study, we assessed the genome-wide transcriptional expression pattern associated with the CRISPR/Cas9-mutated MSTN gene in the olive flounder (
Paralichthys olivaceus
) in association with changes in cell proliferation and transportation processes. There were no differences in the hepatosomatic index, and the growth of male and female fish increased in the F1 progeny of the MSTN mutants. Furthermore, the histopathological analysis showed that myostatin editing resulted in a 41.24% increase in back muscle growth and 46.92% increase in belly muscle growth in male flounder compared with normal flounder, and a 16.01% increase in back muscle growth and 14.26% increase in belly muscle growth in female flounder compared with normal flounder. This study demonstrates that editing of the myostatin gene enhances muscle growth in olive flounder, with a notably more pronounced effect observed in males. Consequently, myostatin-edited male flounder could represent a valuable asset for the flounder aquaculture industry.</description><subject>Animal tissues</subject><subject>Animals</subject><subject>Aquaculture</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Cell proliferation</subject><subject>CRISPR</subject><subject>CRISPR-Cas Systems</subject><subject>Editing</subject><subject>Engineering</subject><subject>Female</subject><subject>Females</subject><subject>Fish</subject><subject>Fish Proteins - genetics</subject><subject>Fish Proteins - metabolism</subject><subject>Fisheries</subject><subject>Fishing</subject><subject>Flounder</subject><subject>Flounder - genetics</subject><subject>Flounder - growth & development</subject><subject>Flounder - metabolism</subject><subject>Freshwater & Marine Ecology</subject><subject>Gene Editing</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genomes</subject><subject>Growth factors</subject><subject>Histopathology</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Males</subject><subject>Marine fishes</subject><subject>Microbiology</subject><subject>MSTN gene</subject><subject>Muscle Development - genetics</subject><subject>Muscle, Skeletal - growth & development</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscles</subject><subject>Musculoskeletal system</subject><subject>Mutants</subject><subject>Mutation</subject><subject>Myostatin</subject><subject>Myostatin - genetics</subject><subject>Myostatin - metabolism</subject><subject>Offspring</subject><subject>Paralichthys olivaceus</subject><subject>Progeny</subject><subject>R&D</subject><subject>Radio frequency identification</subject><subject>Research & development</subject><subject>Science</subject><subject>Seafood</subject><subject>Seawater</subject><subject>Skeletal muscle</subject><subject>Transforming growth factor-b</subject><subject>Zoology</subject><issn>1436-2228</issn><issn>1436-2236</issn><issn>1436-2236</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1OGzEUha2Kqvy0L9AFssQmLKb1H7ZZAiKhEpBKTdeWx75DBk3s1PaA8vYYQqnUBStbut85vvKH0FdKvlFC1PdMCWWyIUw0lHDGms0HtEcFlw1jXO683ZneRfs535MaUpx8QrtcS83Fid5D5Szn6Hpb-hjwOZRHgIBvxuwGwLMUH8sS2-DxItmQXerXL1zssK1QsaHgm1-LWzyDALgPeD70D4CnQxyDh4QnP22yQ--WZbnJONahdTDm48_oY2eHDF9ezwP0e3q5uLhqruezHxdn143jTJZGEWIVE5Rzrf0ptF7JtuuoF0ywthOMaw-yAwoelBDMKeGdhbbtdCu99p4foMm2d53inxFyMas-OxgGGyCO2XAitKo_QWlFj_5D7-OYQt2uUlIzrk70aaXYlnIp5pygM-vUr2zaGErMsxOzdWKqE_PixGxq6PC1emxX4N8ifyVUgG-BXEfhDtK_t9-pfQIzS5hk</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Kim, Ju-Won</creator><creator>Kim, Julan</creator><creator>Cho, Ja Young</creator><creator>Shin, Younhee</creator><creator>Son, Hyojung</creator><creator>Sathiyamoorthy, Subramaniyam</creator><creator>Kim, Bo-Seong</creator><creator>Kim, Young-Ok</creator><creator>Kang, Byeong-chul</creator><creator>Kong, Hee Jeong</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7TN</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H94</scope><scope>H95</scope><scope>H98</scope><scope>H99</scope><scope>K9.</scope><scope>L.F</scope><scope>L.G</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20240601</creationdate><title>Association Between Muscle Growth and Transcription of a Mutant MSTN Gene in Olive Flounder (Paralichthys olivaceus)</title><author>Kim, Ju-Won ; Kim, Julan ; Cho, Ja Young ; Shin, Younhee ; Son, Hyojung ; Sathiyamoorthy, Subramaniyam ; Kim, Bo-Seong ; Kim, Young-Ok ; Kang, Byeong-chul ; Kong, Hee Jeong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-700a72413388d9ebd76bff1d4242bf4238de6fe1ede7442c74dcaebbf8b6d8dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animal tissues</topic><topic>Animals</topic><topic>Aquaculture</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Cell proliferation</topic><topic>CRISPR</topic><topic>CRISPR-Cas Systems</topic><topic>Editing</topic><topic>Engineering</topic><topic>Female</topic><topic>Females</topic><topic>Fish</topic><topic>Fish Proteins - genetics</topic><topic>Fish Proteins - metabolism</topic><topic>Fisheries</topic><topic>Fishing</topic><topic>Flounder</topic><topic>Flounder - genetics</topic><topic>Flounder - growth & development</topic><topic>Flounder - metabolism</topic><topic>Freshwater & Marine Ecology</topic><topic>Gene Editing</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genomes</topic><topic>Growth factors</topic><topic>Histopathology</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Males</topic><topic>Marine fishes</topic><topic>Microbiology</topic><topic>MSTN gene</topic><topic>Muscle Development - genetics</topic><topic>Muscle, Skeletal - growth & development</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscles</topic><topic>Musculoskeletal system</topic><topic>Mutants</topic><topic>Mutation</topic><topic>Myostatin</topic><topic>Myostatin - genetics</topic><topic>Myostatin - metabolism</topic><topic>Offspring</topic><topic>Paralichthys olivaceus</topic><topic>Progeny</topic><topic>R&D</topic><topic>Radio frequency identification</topic><topic>Research & development</topic><topic>Science</topic><topic>Seafood</topic><topic>Seawater</topic><topic>Skeletal muscle</topic><topic>Transforming growth factor-b</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Ju-Won</creatorcontrib><creatorcontrib>Kim, Julan</creatorcontrib><creatorcontrib>Cho, Ja Young</creatorcontrib><creatorcontrib>Shin, Younhee</creatorcontrib><creatorcontrib>Son, Hyojung</creatorcontrib><creatorcontrib>Sathiyamoorthy, Subramaniyam</creatorcontrib><creatorcontrib>Kim, Bo-Seong</creatorcontrib><creatorcontrib>Kim, Young-Ok</creatorcontrib><creatorcontrib>Kang, Byeong-chul</creatorcontrib><creatorcontrib>Kong, Hee Jeong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Aquaculture Abstracts</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Marine biotechnology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Ju-Won</au><au>Kim, Julan</au><au>Cho, Ja Young</au><au>Shin, Younhee</au><au>Son, Hyojung</au><au>Sathiyamoorthy, Subramaniyam</au><au>Kim, Bo-Seong</au><au>Kim, Young-Ok</au><au>Kang, Byeong-chul</au><au>Kong, Hee Jeong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Between Muscle Growth and Transcription of a Mutant MSTN Gene in Olive Flounder (Paralichthys olivaceus)</atitle><jtitle>Marine biotechnology (New York, N.Y.)</jtitle><stitle>Mar Biotechnol</stitle><addtitle>Mar Biotechnol (NY)</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>26</volume><issue>3</issue><spage>599</spage><epage>608</epage><pages>599-608</pages><issn>1436-2228</issn><issn>1436-2236</issn><eissn>1436-2236</eissn><abstract>Myostatin (MSTN, also known as growth differentiation factor-8 (GDF-8)), a member of the transforming growth factor β (TGF-β) superfamily, functions as a negative regulator of skeletal muscle development and growth. However, it is also expressed in a wide range of tissues in fish and thus may have more diverse roles in this group than in mammals. In this study, we assessed the genome-wide transcriptional expression pattern associated with the CRISPR/Cas9-mutated MSTN gene in the olive flounder (
Paralichthys olivaceus
) in association with changes in cell proliferation and transportation processes. There were no differences in the hepatosomatic index, and the growth of male and female fish increased in the F1 progeny of the MSTN mutants. Furthermore, the histopathological analysis showed that myostatin editing resulted in a 41.24% increase in back muscle growth and 46.92% increase in belly muscle growth in male flounder compared with normal flounder, and a 16.01% increase in back muscle growth and 14.26% increase in belly muscle growth in female flounder compared with normal flounder. This study demonstrates that editing of the myostatin gene enhances muscle growth in olive flounder, with a notably more pronounced effect observed in males. Consequently, myostatin-edited male flounder could represent a valuable asset for the flounder aquaculture industry.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38683458</pmid><doi>10.1007/s10126-024-10322-y</doi><tpages>10</tpages></addata></record> |
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| subjects | Animal tissues Animals Aquaculture Biomedical and Life Sciences Biotechnology Cell proliferation CRISPR CRISPR-Cas Systems Editing Engineering Female Females Fish Fish Proteins - genetics Fish Proteins - metabolism Fisheries Fishing Flounder Flounder - genetics Flounder - growth & development Flounder - metabolism Freshwater & Marine Ecology Gene Editing Gene expression Genes Genomes Growth factors Histopathology Life Sciences Male Males Marine fishes Microbiology MSTN gene Muscle Development - genetics Muscle, Skeletal - growth & development Muscle, Skeletal - metabolism Muscles Musculoskeletal system Mutants Mutation Myostatin Myostatin - genetics Myostatin - metabolism Offspring Paralichthys olivaceus Progeny R&D Radio frequency identification Research & development Science Seafood Seawater Skeletal muscle Transforming growth factor-b Zoology |
| title | Association Between Muscle Growth and Transcription of a Mutant MSTN Gene in Olive Flounder (Paralichthys olivaceus) |
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