Cellular senescence in lung cancer: Molecular mechanisms and therapeutic interventions

Lung cancer stands as the primary contributor to cancer-related fatalities worldwide, affecting both genders. Two primary types exist where non-small cell lung cancer (NSCLC), accounts for 80–85% and SCLC accounts for 10–15% of cases. NSCLC subtypes include adenocarcinoma, squamous cell carcinoma, a...

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Veröffentlicht in:Ageing research reviews 2024-06, Vol.97, p.102315, Article 102315
Hauptverfasser: Jha, Saurav Kumar, De Rubis, Gabriele, Devkota, Shankar Raj, Zhang, Yali, Adhikari, Radhika, Jha, Laxmi Akhileshwar, Bhattacharya, Kunal, Mehndiratta, Samir, Gupta, Gaurav, Singh, Sachin Kumar, Panth, Nisha, Dua, Kamal, Hansbro, Philip M., Paudel, Keshav Raj
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Sprache:eng
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Zusammenfassung:Lung cancer stands as the primary contributor to cancer-related fatalities worldwide, affecting both genders. Two primary types exist where non-small cell lung cancer (NSCLC), accounts for 80–85% and SCLC accounts for 10–15% of cases. NSCLC subtypes include adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. Smoking, second-hand smoke, radon gas, asbestos, and other pollutants, genetic predisposition, and COPD are lung cancer risk factors. On the other hand, stresses such as DNA damage, telomere shortening, and oncogene activation cause a prolonged cell cycle halt, known as senescence. Despite its initial role as a tumor-suppressing mechanism that slows cell growth, excessive or improper control of this process can cause age-related diseases, including cancer. Cellular senescence has two purposes in lung cancer. Researchers report that senescence slows tumor growth by constraining multiplication of impaired cells. However, senescent cells also demonstrate the pro-inflammatory senescence-associated secretory phenotype (SASP), which is widely reported to promote cancer. This review will look at the role of cellular senescence in lung cancer, describe its diagnostic markers, ask about current treatments to control it, look at case studies and clinical trials that show how senescence-targeting therapies can be used in lung cancer, and talk about problems currently being faced, and possible solutions for the same in the future. •Defective senescent cells stimulate the development of lung cancer.•The rejuvenation biotechnology sector has prioritized targeting senescence cells.•Senescence-associated secretory phenotype (SASP) fosters the development of tumors.•Medications known as senolytics can selectively eradicate senescent cells.
ISSN:1568-1637
1872-9649
1872-9649
DOI:10.1016/j.arr.2024.102315