Ultrastructural, molecular and haemato-immunological changes: Multifaceted toxicological effects of microcystin-LR in rohu, Labeo rohita

Ultrastructural, molecular and haemato-immunological changes: Multifaceted toxicological effects of microcystin-LR in rohu, Labeo rohita

No water body is resilient to afflicts of algal bloom, if goes unmanaged. With the increasing trend of intensification, eutrophication and climate change, Labeo rohita (rohu) is highly anticipated to suffer from the deleterious effects of bloom and eventually its toxins. A comprehensive study was co...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemosphere (Oxford) 2024-06, Vol.358, p.142097-142097, Article 142097
Hauptverfasser: Mohanty, Snatashree, Paul, Anirban, Banerjee, Sagar, Rajendran, K.V., Tripathi, Gayatri, Das, Pratap Chandra, Sahoo, Pramoda Kumar
Format: Artikel
Sprache:eng
Schlagworte:
Acute toxicity
algal blooms
Animals
Apoptosis
biomarkers
caspase-9
climate change
Cyprinidae
eutrophication
fish
gene expression
genotoxicity
histopathology
Immunity, Innate - drug effects
immunosuppression
interleukin-10
intraperitoneal injection
Kidney - drug effects
kidneys
Labeo rohita
liver
Liver - drug effects
Marine Toxins - toxicity
Microcystin-LR
Microcystins - toxicity
oxidative stress
Oxidative Stress - drug effects
Pathophysiology
poisoning
surface water
transmission electron microscopes
vulnerable species
Water Pollutants, Chemical - toxicity
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:No water body is resilient to afflicts of algal bloom, if goes unmanaged. With the increasing trend of intensification, eutrophication and climate change, Labeo rohita (rohu) is highly anticipated to suffer from the deleterious effects of bloom and eventually its toxins. A comprehensive study was conducted to understand the toxicopathological effects of microcystin-LR (MC-LR) in rohu following intraperitoneal injection of 96 h-LD50 dose i.e., 713 μg kg−1. Substantial changes in micro- and ultrastructural level were evident in histopathology and transmission electron microscope (TEM) study. The haematological, biochemical, cellular and humoral innate immune biomarkers were significantly altered (p 
ISSN:0045-6535
1879-1298
DOI:10.1016/j.chemosphere.2024.142097