Sequential CD7 CAR T-Cell Therapy and Allogeneic HSCT without GVHD Prophylaxis

Of 10 patients with relapsed or refractory hematologic cancers who received sequential CAR T-cell infusion followed by allogeneic stem-cell transplantation without GVHD prophylaxis, 6 were alive and disease-free at last follow-up.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2024-04, Vol.390 (16), p.1467-1480
Hauptverfasser:	Hu, Yongxian, Zhang, Mingming, Yang, Tingting, Mo, Zhuomao, Wei, Guoqing, Jing, Ruirui, Zhao, Houli, Chen, Rongrong, Zu, Cheng, Gu, Tianning, Xiao, Pingnan, Hong, Ruimin, Feng, Jingjing, Fu, Shan, Kong, Delin, Xu, Huijun, Cui, Jiazhen, Huang, Simao, Liang, Bin, Yuan, Xiaolin, Cui, Qu, Guo, Hongshan, Yu, Yunxian, Feng, Youqin, Jin, Chunxiang, Ren, Jiangtao, Chang, Alex H., Wang, Dongrui, Huang, He
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Allografts Antigens, CD7 Antitumor activity Blood cancer Bone marrow Bone Marrow Transplantation CD7 antigen Cell therapy Chimeric antigen receptors Chimerism Combined Modality Therapy Cytokine storm Cytomegalovirus Disease prevention Encephalitis Enrollments Female Graft versus host disease Graft vs Host Disease - prevention & control Graft-versus-host reaction Hematology Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - methods Hematopoietic stem cells Hemopoiesis Humans Immunosuppressive agents Immunotherapy, Adoptive - adverse effects Immunotherapy, Adoptive - methods Infections Leukemia Leukemia - mortality Leukemia - therapy Lymphocytes Lymphocytes T Lymphoma Lymphoma - mortality Lymphoma - therapy Male Medical prognosis Middle Aged Minimal residual disease Oncology Pancytopenia Patients Prophylaxis Receptors, Chimeric Antigen - therapeutic use Recurrence Remission Remission (Medicine) Remission Induction Sepsis Septic shock Stem cell transplantation Tomography Transplantation, Homologous Treatments in Oncology Tumors Young Adult
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Beschreibung
Zusammenfassung:	Of 10 patients with relapsed or refractory hematologic cancers who received sequential CAR T-cell infusion followed by allogeneic stem-cell transplantation without GVHD prophylaxis, 6 were alive and disease-free at last follow-up.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa2313812