Efficient synthesis of SCF3-containing 3-alkenylquinoxalinones via three-component radical cascade reaction

Efficient synthesis of SCF3-containing 3-alkenylquinoxalinones via three-component radical cascade reaction

An efficient and practical method for the synthesis of 3-alkenylquinoxalinones containing the SCF3 group has been readily developed through a three-component radical cascade reaction involving quinoxalinones, alkynes and AgSCF3. The reaction was found to be compatible with a variety of substrates an...

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Veröffentlicht in:Organic & biomolecular chemistry 2024-05, Vol.22 (18), p.3740-3745
Hauptverfasser: Si-Yu, Wang, Chu, Liu, Yang, Wei, Zhong-Ying, Tian, Lin, Yuan, Long-Yong, Xie
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes
Cascade chemical reactions
Functional groups
Substrates
Synthesis
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Zusammenfassung:An efficient and practical method for the synthesis of 3-alkenylquinoxalinones containing the SCF3 group has been readily developed through a three-component radical cascade reaction involving quinoxalinones, alkynes and AgSCF3. The reaction was found to be compatible with a variety of substrates and exhibited a high functional group tolerance and complete E-selectivity. The preliminary study suggests the involvement of a SCF3 radical in the transformation.
ISSN:1477-0520
1477-0539
DOI:10.1039/d4ob00363b