Characteristics, management and outcome of Herpes Simplex and Varicella-Zoster virus encephalitis: a multicentre prospective cohort study

Characteristics, management and outcome of Herpes Simplex and Varicella-Zoster virus encephalitis: a multicentre prospective cohort study

To characterize differences between Herpes Simplex virus encephalitis and Varicella-Zoster virus encephalitis (HSVE and VZVE) and other aetiologies of infectious encephalitis (IE), and to investigate the impact of time-to-aciclovir (ACV) start, ACV dose and duration on outcome. We compared 132 HSVE,...

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Veröffentlicht in:Clinical microbiology and infection 2024-07, Vol.30 (7), p.917-923
Hauptverfasser: Mailles, Alexandra, Stahl, Jean-Paul, Fillâtre, Pierre, Argaud, Laurent, Argemi, Xavier, Asseray, Nathalie, Blanchet-Fourcade, Geneviève, Blot, Mathieu, Bonnetain, Anne, Bourdain, Frédéric, Bruel, Cédric, Bruneel, Fabrice, Buzele, Rodolphe, Canouï, Etienne, Casenave, Philippe, Castan, Bernard, Cazanave, Charles, Cazorla, Céline, Chavanet, Pascal, Chirouze, Catherine, Courjon, Johan, de Montmollin, Etienne, Degroote, Thècle, Delaroche, Marine, Deschanvres, Colin, Diard-Detoeuf, Capucine, Dinh, Aurélien, Epaulard, Olivier, Fillatre, Pierre, Fraisse, Thibault, Gaborit, Benjamin, Gagneux-Brunon, Amandine, Gaillard, Nicolas, Godement, Mathieu, Goehringer, François, Gueit, Isabelle, Guimard, Thomas, Henry, Carole, Hentzien, Maxime, Jaquet, Pierre, Jommier, Fanny, Katchatourian, Lydie, Le Cam, Manuela, Le Maréchal, Marion, Le Moal, Gwenael, Le Turnier, Paul, Lefaucheur, Romain, Lejeune, Stéphanie, Lescure, Xavier, Lesieur, Olivier, Lesprit, Philippe, Louis, Guillaume, Mahieu, Rafael, Makinson, Alain, Marc, Guillaune, Maria, Alexandre, Marin, Nathalie, Martin, Aurélie, Martin-Blondel, Guillaume, Mateu, Philippe, Matt, Morgan, Maulin, Laurence, Mechai, Frédéric, Mutez, Eugénie, Orain, Jérémie, Schieber-Pachart, Anne, Pansu, Nathalie, Pavese, Patricia, Pelerin, Hélène, Pelonde-Erimée, Véronique, Ponscarme, Diane, Puges, Mathilde, Reveillon-Istin, Mathilde, Rheims, Sylvain, Richard-Mornas, Aurélie, Riché, Agnès, Ruch, Yvon, Runge, Isabelle, Tattevin, Pierre, Tiercelet, Kelly, Touati, Saber, Turmel, Jean-Marie, Tyvaert, Isabelle, Vareil, Marc-Olivier, Vitrat, Virginie, Wille, Heidi, Reignier, Jean, Wang, Adrien, Julien, Gautier, Almoyna-Martinez, Laurent, Bouchaud, Olivier, Girard, Nadine, Herrmann, Jean-Louis, Honnorat, Jérome, Morand, Patrice, Raffi, François, Sonneville, Romain
Format: Artikel
Sprache:eng
Schlagworte:
Acyclovir
Herpes Simplex virus
Infectious encephalitis
Outcome
Varicella-Zoster virus
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Zusammenfassung:To characterize differences between Herpes Simplex virus encephalitis and Varicella-Zoster virus encephalitis (HSVE and VZVE) and other aetiologies of infectious encephalitis (IE), and to investigate the impact of time-to-aciclovir (ACV) start, ACV dose and duration on outcome. We compared 132 HSVE, 65 VZVE and 297 other IE enrolled in a prospective cohort (ENCEIF). We estimated associations between time-to-ACV start, dose or duration and outcome through adjusted odds ratio (aOR) using logistic regression analysis. Prevalence of immunodepression differed among aetiologies: 15/65 (23%) for VZVE, 13/132 (10%) for HSVE and 30/297 (10%) for other IE (p
ISSN:1198-743X
1469-0691
1469-0691
DOI:10.1016/j.cmi.2024.03.017