Gradually Self‐Strengthen DNA Supramolecular Hydrogels

The dynamic mechanical strength of the extracellular matrix (ECM) has been demonstrated to play important role in determining the cell behavior. Growing evidences suggest that the gradual stiffening process of the matrix is particularly decisive during tissue development and wound healing. Herein, a...

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Veröffentlicht in:Macromolecular rapid communications. 2024-08, Vol.45 (16), p.e2400177-n/a
Hauptverfasser: Du, Xiuji, Xing, Yongzheng, Li, Yujie, Cao, Muqing, Wu, Jun, Dong, Guizhi, Shi, Ziwei, Wei, Xunan, Qiu, Miaomiao, Gao, Junjie, Xu, Yun, Xu, Huaping, Liu, Dongsheng, Dong, Yuanchen
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Sprache:eng
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Zusammenfassung:The dynamic mechanical strength of the extracellular matrix (ECM) has been demonstrated to play important role in determining the cell behavior. Growing evidences suggest that the gradual stiffening process of the matrix is particularly decisive during tissue development and wound healing. Herein, a novel strategy to prepare hydrogels with gradually enhanced mechanical strength is provided. Such hydrogels could maintain the dynamic properties at their initial states, such as self‐healing and shear‐thinning properties. With subsequent slow covalent crosslinking, the stability and mechanical properties would be gradually improved. This method is useful for sequence programmability and oxidation strategies, which has provided an alternated tool to study cell behavior during dynamic increase in mechanical strength of ECM. A series of gradually strengthened DNA supramolecular hydrogels have been constructed for simulating gradual stiffing of extracellular matrix. In the initial states, the supramolecular hydrogels possess dynamic properties, which endow them with shear‐thinning, self‐healing, and injectability. With subsequent slow covalent crosslinking, the mechanical properties of the DNA supramolecular hydrogels would be gradually improved compared to the initial state.
ISSN:1022-1336
1521-3927
1521-3927
DOI:10.1002/marc.202400177