Chemiluminescence-Based IgE Dot-Blot Assay in the Diagnosis of Anaphylaxis Caused by Prontosan

A 91-year-old man developed a severe anaphylaxis episode after topical administration of Prontosan as an antiseptic to treat skin ulcers on the lower limbs. The episode was treated with intravenous fluid therapy, intravenous corticosteroid therapy, and antihistamines. Two days later, during a second, accidental exposure, the patient developed hives with pruritus, nasal obstruction, and ear plugging, which resolved with antihistamines. The patient had previously experienced urticaria episodes following topical administration of Prontosan. Although chlorhexidine had not been applied prior to the episode of anaphylaxis, the patient's daughter reported an episode of urticaria after administration of topical chlorhexidine during a subsequent admission to hospital. No other drug or environmental allergic sensitizations have been reported to date. The patient gave his written informed consent for the study to be performed.