The potential value of a quantitative PCR assay for assessing respiratory samples in approaching a laboratory diagnosis of pulmonary mucormycosis

•Mucorales qPCR aids in the aetiological diagnosis of breakthrough invasive fungal infections not responding to Aspergillus-targeted therapy.•Narrow hyphal widths (3−7 µm) were observed on histology of mucormycosis caused by Cunninghamella bertholletiae, which could be differentiated from aspergillo...

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Veröffentlicht in:	The Journal of infection 2024-06, Vol.88 (6), p.106160-106160, Article 106160
Hauptverfasser:	Chen, Ya-Ping, Cia, Cong-Tat, Hsu, Ya-Ting, Chen, Po-Lin, Chen, Tsai-Yun, Lee, Jen-Chieh, Li, Sin-Syue, Hsieh, Ming-I, Wang, Hsuan-Chen, Wu, Chi-Jung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Female Humans Lung Diseases, Fungal - diagnosis Lung Diseases, Fungal - microbiology Male Middle Aged Mucormycosis - diagnosis Mucormycosis - microbiology Real-Time Polymerase Chain Reaction - methods Sensitivity and Specificity
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Beschreibung
Zusammenfassung:	•Mucorales qPCR aids in the aetiological diagnosis of breakthrough invasive fungal infections not responding to Aspergillus-targeted therapy.•Narrow hyphal widths (3−7 µm) were observed on histology of mucormycosis caused by Cunninghamella bertholletiae, which could be differentiated from aspergillosis by Mucorales qPCR using fresh lung tissue.•Further refinement of Mucorales qPCR assays for specific detection of C. bertholletiae aids in pathogen-tailored management.
ISSN:	0163-4453 1532-2742
DOI:	10.1016/j.jinf.2024.106160