Towards fair and clinically relevant polygenic predictions

Towards fair and clinically relevant polygenic predictions

Lennon et al. recently proposed a clinical polygenic score (PGS) pipeline as part of the Electronic Medical Records and Genomics (eMERGE) network initiative. In this spotlight article we discuss the broader context for the use of PGS in preventive medicine and highlight key limitations and challenge...

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Veröffentlicht in:Trends in genetics 2024-05, Vol.40 (5), p.379-380
1. Verfasser: Vilhjálmsson, Bjarni Jóhann
Format: Artikel
Sprache:eng
Schlagworte:
clinical risk assessment
diverse ancestry
polygenic scores
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Zusammenfassung:Lennon et al. recently proposed a clinical polygenic score (PGS) pipeline as part of the Electronic Medical Records and Genomics (eMERGE) network initiative. In this spotlight article we discuss the broader context for the use of PGS in preventive medicine and highlight key limitations and challenges facing their inclusion in prediction models. Lennon et al. recently proposed a clinical polygenic score (PGS) pipeline as part of the Electronic Medical Records and Genomics (eMERGE) network initiative. In this spotlight article we discuss the broader context for the use of PGS in preventive medicine and highlight key limitations and challenges facing their inclusion in prediction models.
ISSN:0168-9525
DOI:10.1016/j.tig.2024.04.002