Unraveling the immune response of the spleen in sepsis using green‐synthesized silver nanoparticles from pomegranate peel extracts

Sepsis is a serious disease characterized by an inappropriate host response to infection, resulting in widespread inflammation and systemic organ failure. The aim of this research is to investigate the possibility of pomegranate peel‐derived silver nanoparticles (PGNP) as a potential alternative the...

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Veröffentlicht in:	Microscopy research and technique 2024-09, Vol.87 (9), p.2034-2042
Hauptverfasser:	Marey, Amal M., Dkhil, Mohamed A., Abdel‐Moneim, Ahmed E., Santourlidis, Simeon, Abdel‐Gaber, Rewaida, Abdalla, Mohga S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotic resistance Apoptosis BAX protein Gene expression Glutathione Histology Immune response Immune system Immunology Impact resistance Inflammation Nanoparticles nanosilver Nitric oxide Oxidative stress Plant extracts pomegranate Proteins rats Sepsis Silver Spleen spleen response Superoxide dismutase Transmission electron microscopy
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Zusammenfassung:	Sepsis is a serious disease characterized by an inappropriate host response to infection, resulting in widespread inflammation and systemic organ failure. The aim of this research is to investigate the possibility of pomegranate peel‐derived silver nanoparticles (PGNP) as a potential alternative therapy for sepsis. Characterization using transmission electron microscopy revealed 10–30 nm spherical nanoparticles. In a rat model of sepsis, PGNP treatment improved spleen health, histology, and immune response as compared with septic rats. In rats treated with PGNP during sepsis, significant alterations in oxidative stress markers (p
ISSN:	1059-910X 1097-0029 1097-0029
DOI:	10.1002/jemt.24575