CD-MOFs: From preparation to drug delivery and therapeutic application

CD-MOFs: From preparation to drug delivery and therapeutic application

Cyclodextrin metal-organic frameworks (CD-MOFs) show considerable advantages of edibility, degradability, low toxicity, and high drug loading, which have attracted enormous interest, especially in drug delivery. This review summarizes the typical synthesis approaches of CD-MOFs, the drug loading met...

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Veröffentlicht in:Carbohydrate polymers 2024-01, Vol.323, p.121424-121424, Article 121424
Hauptverfasser: Si, Yanxue, Luo, Huize, Zhang, Pai, Zhang, Chunliang, Li, Juanjuan, Jiang, Peng, Yuan, Wenbing, Cha, Ruitao
Format: Artikel
Sprache:eng
Schlagworte:
aqueous solutions
biosafety
Cyclodextrin metal organic frameworks
cyclodextrins
Drug encapsulation
Drug release
drugs
encapsulation
Synthesis approaches
Therapeutic application
therapeutics
toxicity
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Zusammenfassung:Cyclodextrin metal-organic frameworks (CD-MOFs) show considerable advantages of edibility, degradability, low toxicity, and high drug loading, which have attracted enormous interest, especially in drug delivery. This review summarizes the typical synthesis approaches of CD-MOFs, the drug loading methods, and the mechanism of encapsulation and release. The influence of the structure of CD-MOFs on their drug encapsulation and release is highlighted. Finally, the challenges CD-MOFs face are discussed regarding biosafety assessment systems, stability in aqueous solution, and metal ion effect.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2023.121424