Effect of theophylline on stent-related symptoms in patients undergoing Double-J ureteral stent insertion: a randomized controlled trial
Purpose To investigate the effect of oral theophylline on stent-related syndrome (SRS) after Double-J insertion. Background Double-J stent is widely using in many urological procedures. Infection, hematuria, and discomfort are some of common complication after stenting. Theophylline is a dimethylate...
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| Veröffentlicht in: | International urology and nephrology 2024-09, Vol.56 (9), p.2897-2903 |
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| creator | Pakdel, Alireza Mohammadi, Abdolreza Chivaee, Hossein Shamshirgaran, Amirreza Amirzargar, Hossein Farsani, Reza Mohammadi Asgari, Fardin Khajavi, Alireza Aghamir, Seyed Mohammad Kazem |
| description | Purpose
To investigate the effect of oral theophylline on stent-related syndrome (SRS) after Double-J insertion.
Background
Double-J stent is widely using in many urological procedures. Infection, hematuria, and discomfort are some of common complication after stenting. Theophylline is a dimethylated xanthine that inhibits phosphodiesterase and blocks adenosine receptors. To relaxing effect of theophylline on smooth muscles and its effects on the urinary system, it seems it could reduce complications after inserting Double-J stent especially ureteral stent syndrome.
Method
In this double-blind placebo-controlled randomized clinical trial, 67 patients were enrolled. Mean (SD) age of control and theophylline group was 51.8 (12.5) and 43.9 (10.4) years old, respectively. Patients were randomized into two groups of control and theophylline. All patients were stenting with silicon Double J. Theophylline group received 100 mg of theophylline, twice daily for 30 days, while control group received placebo. Stent symptoms were assessed by questionnaire and urine culture was performed before stent removal at removal day. Statistical analysis was performed using Chi-squared test and
t
test with
P
|
| doi_str_mv | 10.1007/s11255-024-04049-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3040333658</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3040333658</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-fdb258edb00927dd8eae8bb0765b408016842f58c984ea72023c8c4a1ffb5e833</originalsourceid><addsrcrecordid>eNp9kctu1jAQhSMEoqXwAiyQJTZsDONLEocdKuWmSmxgbTnJ-K8rxw62I_XnCXhsDCkXsWA1I813znh8muYxg-cMoH-RGeNtS4FLChLkQG_uNKes7QXlrZJ3_-pPmgc5XwPAoADuNydCdQIkV6fNtwtrcSokWlKuMK5XR-9dQBIDyQVDoQm9KTiTfFzWEpdMXCCrKa7OMtnCjOkQXTiQ13EbPdIPZEtYMBm_6yueMRUXw0tiSDJhjov7Wv2mGEqK3te2JGf8w-aeNT7jo9t61nx-c_Hp_B29_Pj2_fmrSzoJ3hVq57EehPNYb-H9PCs0qMYR-q4dJShgnZLctmoalETTc-BiUpM0zNqxRSXEWfNs911T_LJhLnpxeULvTcC4ZV3_BYQQXasq-vQf9DpuKdTXVWrgcmAMhkrxnZpSzDmh1Wtyi0lHzUD_yEnvOemak_6Zk76poie31tu44Pxb8iuYCogdyHUUDpj-7P6P7XfUvaD7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3092491109</pqid></control><display><type>article</type><title>Effect of theophylline on stent-related symptoms in patients undergoing Double-J ureteral stent insertion: a randomized controlled trial</title><source>SpringerLink Journals - AutoHoldings</source><creator>Pakdel, Alireza ; Mohammadi, Abdolreza ; Chivaee, Hossein ; Shamshirgaran, Amirreza ; Amirzargar, Hossein ; Farsani, Reza Mohammadi ; Asgari, Fardin ; Khajavi, Alireza ; Aghamir, Seyed Mohammad Kazem</creator><creatorcontrib>Pakdel, Alireza ; Mohammadi, Abdolreza ; Chivaee, Hossein ; Shamshirgaran, Amirreza ; Amirzargar, Hossein ; Farsani, Reza Mohammadi ; Asgari, Fardin ; Khajavi, Alireza ; Aghamir, Seyed Mohammad Kazem</creatorcontrib><description>Purpose
To investigate the effect of oral theophylline on stent-related syndrome (SRS) after Double-J insertion.
Background
Double-J stent is widely using in many urological procedures. Infection, hematuria, and discomfort are some of common complication after stenting. Theophylline is a dimethylated xanthine that inhibits phosphodiesterase and blocks adenosine receptors. To relaxing effect of theophylline on smooth muscles and its effects on the urinary system, it seems it could reduce complications after inserting Double-J stent especially ureteral stent syndrome.
Method
In this double-blind placebo-controlled randomized clinical trial, 67 patients were enrolled. Mean (SD) age of control and theophylline group was 51.8 (12.5) and 43.9 (10.4) years old, respectively. Patients were randomized into two groups of control and theophylline. All patients were stenting with silicon Double J. Theophylline group received 100 mg of theophylline, twice daily for 30 days, while control group received placebo. Stent symptoms were assessed by questionnaire and urine culture was performed before stent removal at removal day. Statistical analysis was performed using Chi-squared test and
t
test with
P
< 0.05 considered significant. Logistic regression models were fitted, crudely and adjusted for age and sex.
Result
Of 67 eligible patients, 60 completed the study. Theophylline significantly decreased percentages of gross hematuria (
P
< 0.001), dysuria (
P
< 0.001), and urinary frequency (
P
< 0.001). Microscopic hematuria (
P
= 0.042) and chills (
P
= 0.042) also decreased after theophylline.
Conclusion
Theophylline could be an effective and safe choice for reducing SRS among patients undergoing Double-J stent insertion.</description><identifier>ISSN: 1573-2584</identifier><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-024-04049-x</identifier><identifier>PMID: 38630428</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adenosine receptors ; Clinical trials ; Hematuria ; Implants ; Medicine ; Medicine & Public Health ; Nephrology ; Placebos ; Regression analysis ; Statistical analysis ; Statistical models ; Theophylline ; Ureteral stents ; Urology ; Urology - Original Paper</subject><ispartof>International urology and nephrology, 2024-09, Vol.56 (9), p.2897-2903</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Nature B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-fdb258edb00927dd8eae8bb0765b408016842f58c984ea72023c8c4a1ffb5e833</cites><orcidid>0000-0003-1611-0362</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11255-024-04049-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11255-024-04049-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38630428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pakdel, Alireza</creatorcontrib><creatorcontrib>Mohammadi, Abdolreza</creatorcontrib><creatorcontrib>Chivaee, Hossein</creatorcontrib><creatorcontrib>Shamshirgaran, Amirreza</creatorcontrib><creatorcontrib>Amirzargar, Hossein</creatorcontrib><creatorcontrib>Farsani, Reza Mohammadi</creatorcontrib><creatorcontrib>Asgari, Fardin</creatorcontrib><creatorcontrib>Khajavi, Alireza</creatorcontrib><creatorcontrib>Aghamir, Seyed Mohammad Kazem</creatorcontrib><title>Effect of theophylline on stent-related symptoms in patients undergoing Double-J ureteral stent insertion: a randomized controlled trial</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description>Purpose
To investigate the effect of oral theophylline on stent-related syndrome (SRS) after Double-J insertion.
Background
Double-J stent is widely using in many urological procedures. Infection, hematuria, and discomfort are some of common complication after stenting. Theophylline is a dimethylated xanthine that inhibits phosphodiesterase and blocks adenosine receptors. To relaxing effect of theophylline on smooth muscles and its effects on the urinary system, it seems it could reduce complications after inserting Double-J stent especially ureteral stent syndrome.
Method
In this double-blind placebo-controlled randomized clinical trial, 67 patients were enrolled. Mean (SD) age of control and theophylline group was 51.8 (12.5) and 43.9 (10.4) years old, respectively. Patients were randomized into two groups of control and theophylline. All patients were stenting with silicon Double J. Theophylline group received 100 mg of theophylline, twice daily for 30 days, while control group received placebo. Stent symptoms were assessed by questionnaire and urine culture was performed before stent removal at removal day. Statistical analysis was performed using Chi-squared test and
t
test with
P
< 0.05 considered significant. Logistic regression models were fitted, crudely and adjusted for age and sex.
Result
Of 67 eligible patients, 60 completed the study. Theophylline significantly decreased percentages of gross hematuria (
P
< 0.001), dysuria (
P
< 0.001), and urinary frequency (
P
< 0.001). Microscopic hematuria (
P
= 0.042) and chills (
P
= 0.042) also decreased after theophylline.
Conclusion
Theophylline could be an effective and safe choice for reducing SRS among patients undergoing Double-J stent insertion.</description><subject>Adenosine receptors</subject><subject>Clinical trials</subject><subject>Hematuria</subject><subject>Implants</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephrology</subject><subject>Placebos</subject><subject>Regression analysis</subject><subject>Statistical analysis</subject><subject>Statistical models</subject><subject>Theophylline</subject><subject>Ureteral stents</subject><subject>Urology</subject><subject>Urology - Original Paper</subject><issn>1573-2584</issn><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kctu1jAQhSMEoqXwAiyQJTZsDONLEocdKuWmSmxgbTnJ-K8rxw62I_XnCXhsDCkXsWA1I813znh8muYxg-cMoH-RGeNtS4FLChLkQG_uNKes7QXlrZJ3_-pPmgc5XwPAoADuNydCdQIkV6fNtwtrcSokWlKuMK5XR-9dQBIDyQVDoQm9KTiTfFzWEpdMXCCrKa7OMtnCjOkQXTiQ13EbPdIPZEtYMBm_6yueMRUXw0tiSDJhjov7Wv2mGEqK3te2JGf8w-aeNT7jo9t61nx-c_Hp_B29_Pj2_fmrSzoJ3hVq57EehPNYb-H9PCs0qMYR-q4dJShgnZLctmoalETTc-BiUpM0zNqxRSXEWfNs911T_LJhLnpxeULvTcC4ZV3_BYQQXasq-vQf9DpuKdTXVWrgcmAMhkrxnZpSzDmh1Wtyi0lHzUD_yEnvOemak_6Zk76poie31tu44Pxb8iuYCogdyHUUDpj-7P6P7XfUvaD7</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Pakdel, Alireza</creator><creator>Mohammadi, Abdolreza</creator><creator>Chivaee, Hossein</creator><creator>Shamshirgaran, Amirreza</creator><creator>Amirzargar, Hossein</creator><creator>Farsani, Reza Mohammadi</creator><creator>Asgari, Fardin</creator><creator>Khajavi, Alireza</creator><creator>Aghamir, Seyed Mohammad Kazem</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1611-0362</orcidid></search><sort><creationdate>20240901</creationdate><title>Effect of theophylline on stent-related symptoms in patients undergoing Double-J ureteral stent insertion: a randomized controlled trial</title><author>Pakdel, Alireza ; Mohammadi, Abdolreza ; Chivaee, Hossein ; Shamshirgaran, Amirreza ; Amirzargar, Hossein ; Farsani, Reza Mohammadi ; Asgari, Fardin ; Khajavi, Alireza ; Aghamir, Seyed Mohammad Kazem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-fdb258edb00927dd8eae8bb0765b408016842f58c984ea72023c8c4a1ffb5e833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adenosine receptors</topic><topic>Clinical trials</topic><topic>Hematuria</topic><topic>Implants</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nephrology</topic><topic>Placebos</topic><topic>Regression analysis</topic><topic>Statistical analysis</topic><topic>Statistical models</topic><topic>Theophylline</topic><topic>Ureteral stents</topic><topic>Urology</topic><topic>Urology - Original Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pakdel, Alireza</creatorcontrib><creatorcontrib>Mohammadi, Abdolreza</creatorcontrib><creatorcontrib>Chivaee, Hossein</creatorcontrib><creatorcontrib>Shamshirgaran, Amirreza</creatorcontrib><creatorcontrib>Amirzargar, Hossein</creatorcontrib><creatorcontrib>Farsani, Reza Mohammadi</creatorcontrib><creatorcontrib>Asgari, Fardin</creatorcontrib><creatorcontrib>Khajavi, Alireza</creatorcontrib><creatorcontrib>Aghamir, Seyed Mohammad Kazem</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pakdel, Alireza</au><au>Mohammadi, Abdolreza</au><au>Chivaee, Hossein</au><au>Shamshirgaran, Amirreza</au><au>Amirzargar, Hossein</au><au>Farsani, Reza Mohammadi</au><au>Asgari, Fardin</au><au>Khajavi, Alireza</au><au>Aghamir, Seyed Mohammad Kazem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of theophylline on stent-related symptoms in patients undergoing Double-J ureteral stent insertion: a randomized controlled trial</atitle><jtitle>International urology and nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2024-09-01</date><risdate>2024</risdate><volume>56</volume><issue>9</issue><spage>2897</spage><epage>2903</epage><pages>2897-2903</pages><issn>1573-2584</issn><issn>0301-1623</issn><eissn>1573-2584</eissn><abstract>Purpose
To investigate the effect of oral theophylline on stent-related syndrome (SRS) after Double-J insertion.
Background
Double-J stent is widely using in many urological procedures. Infection, hematuria, and discomfort are some of common complication after stenting. Theophylline is a dimethylated xanthine that inhibits phosphodiesterase and blocks adenosine receptors. To relaxing effect of theophylline on smooth muscles and its effects on the urinary system, it seems it could reduce complications after inserting Double-J stent especially ureteral stent syndrome.
Method
In this double-blind placebo-controlled randomized clinical trial, 67 patients were enrolled. Mean (SD) age of control and theophylline group was 51.8 (12.5) and 43.9 (10.4) years old, respectively. Patients were randomized into two groups of control and theophylline. All patients were stenting with silicon Double J. Theophylline group received 100 mg of theophylline, twice daily for 30 days, while control group received placebo. Stent symptoms were assessed by questionnaire and urine culture was performed before stent removal at removal day. Statistical analysis was performed using Chi-squared test and
t
test with
P
< 0.05 considered significant. Logistic regression models were fitted, crudely and adjusted for age and sex.
Result
Of 67 eligible patients, 60 completed the study. Theophylline significantly decreased percentages of gross hematuria (
P
< 0.001), dysuria (
P
< 0.001), and urinary frequency (
P
< 0.001). Microscopic hematuria (
P
= 0.042) and chills (
P
= 0.042) also decreased after theophylline.
Conclusion
Theophylline could be an effective and safe choice for reducing SRS among patients undergoing Double-J stent insertion.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>38630428</pmid><doi>10.1007/s11255-024-04049-x</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-1611-0362</orcidid></addata></record> |
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| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Adenosine receptors Clinical trials Hematuria Implants Medicine Medicine & Public Health Nephrology Placebos Regression analysis Statistical analysis Statistical models Theophylline Ureteral stents Urology Urology - Original Paper |
| title | Effect of theophylline on stent-related symptoms in patients undergoing Double-J ureteral stent insertion: a randomized controlled trial |
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