Effect of theophylline on stent-related symptoms in patients undergoing Double-J ureteral stent insertion: a randomized controlled trial
Purpose To investigate the effect of oral theophylline on stent-related syndrome (SRS) after Double-J insertion. Background Double-J stent is widely using in many urological procedures. Infection, hematuria, and discomfort are some of common complication after stenting. Theophylline is a dimethylate...
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Veröffentlicht in: | International urology and nephrology 2024-09, Vol.56 (9), p.2897-2903 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Purpose
To investigate the effect of oral theophylline on stent-related syndrome (SRS) after Double-J insertion.
Background
Double-J stent is widely using in many urological procedures. Infection, hematuria, and discomfort are some of common complication after stenting. Theophylline is a dimethylated xanthine that inhibits phosphodiesterase and blocks adenosine receptors. To relaxing effect of theophylline on smooth muscles and its effects on the urinary system, it seems it could reduce complications after inserting Double-J stent especially ureteral stent syndrome.
Method
In this double-blind placebo-controlled randomized clinical trial, 67 patients were enrolled. Mean (SD) age of control and theophylline group was 51.8 (12.5) and 43.9 (10.4) years old, respectively. Patients were randomized into two groups of control and theophylline. All patients were stenting with silicon Double J. Theophylline group received 100 mg of theophylline, twice daily for 30 days, while control group received placebo. Stent symptoms were assessed by questionnaire and urine culture was performed before stent removal at removal day. Statistical analysis was performed using Chi-squared test and
t
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ISSN: | 1573-2584 0301-1623 1573-2584 |
DOI: | 10.1007/s11255-024-04049-x |