Radiation‐induced cutaneous squamous cell carcinoma showing a significant response to pembrolizumab: A case report
Cutaneous squamous cell carcinoma (cSCC) arising from radiation dermatitis has a higher risk of metastasis than conventional cSCC. Immunosuppression is another risk factor for cSCC, suggesting that mycosis fungoides (MF) could be a risk factor for cSCC. Here we report a case of radiation‐induced cSC...
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Veröffentlicht in: | Journal of dermatology 2024-11, Vol.51 (11), p.1500-1503 |
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creator | Takahashi‐Watanabe, Manami Fujimura, Taku Amagai, Ryo Ohuchi, Kentaro Yamazaki, Emi Tamabuchi, Erika Kuroki, Shigeru Kambayashi, Yumi Hashimoto, Akira Asano, Yoshihide |
description | Cutaneous squamous cell carcinoma (cSCC) arising from radiation dermatitis has a higher risk of metastasis than conventional cSCC. Immunosuppression is another risk factor for cSCC, suggesting that mycosis fungoides (MF) could be a risk factor for cSCC. Here we report a case of radiation‐induced cSCC with a high level of tumor‐mutation burden that developed in a patient with MF who was successfully treated with pembrolizumab. The present case suggests that pembrolizumab might be an optimal therapy for radiation‐induced cSCC, even at advanced stages. |
doi_str_mv | 10.1111/1346-8138.17221 |
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Immunosuppression is another risk factor for cSCC, suggesting that mycosis fungoides (MF) could be a risk factor for cSCC. Here we report a case of radiation‐induced cSCC with a high level of tumor‐mutation burden that developed in a patient with MF who was successfully treated with pembrolizumab. The present case suggests that pembrolizumab might be an optimal therapy for radiation‐induced cSCC, even at advanced stages.</description><identifier>ISSN: 0385-2407</identifier><identifier>ISSN: 1346-8138</identifier><identifier>EISSN: 1346-8138</identifier><identifier>DOI: 10.1111/1346-8138.17221</identifier><identifier>PMID: 38629702</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Aged ; Antibodies, Monoclonal, Humanized - adverse effects ; Antibodies, Monoclonal, Humanized - therapeutic use ; Antineoplastic Agents, Immunological - adverse effects ; Antineoplastic Agents, Immunological - therapeutic use ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - drug therapy ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - therapy ; Case reports ; Dermatitis ; Humans ; Immunosuppression ; Male ; Metastases ; Mycosis ; Mycosis fungoides ; Mycosis Fungoides - diagnosis ; Mycosis Fungoides - drug therapy ; Mycosis Fungoides - pathology ; Neoplasms, Radiation-Induced - diagnosis ; Neoplasms, Radiation-Induced - drug therapy ; Neoplasms, Radiation-Induced - etiology ; Neoplasms, Radiation-Induced - pathology ; Pembrolizumab ; radiation‐induced cSCC ; Risk factors ; Skin - pathology ; Skin - radiation effects ; Skin Neoplasms - diagnosis ; Skin Neoplasms - drug therapy ; Skin Neoplasms - etiology ; Skin Neoplasms - pathology ; Squamous cell carcinoma ; Treatment Outcome</subject><ispartof>Journal of dermatology, 2024-11, Vol.51 (11), p.1500-1503</ispartof><rights>2024 Japanese Dermatological Association.</rights><rights>Copyright © 2024 Japanese Dermatological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3251-793e4b6bc688fb0381b2c53f089af64cdd08801ded9ea542c2960926002024ca3</cites><orcidid>0000-0001-6809-5833 ; 0009-0008-3337-5657 ; 0000-0003-3866-5609</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1346-8138.17221$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1346-8138.17221$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38629702$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takahashi‐Watanabe, Manami</creatorcontrib><creatorcontrib>Fujimura, Taku</creatorcontrib><creatorcontrib>Amagai, Ryo</creatorcontrib><creatorcontrib>Ohuchi, Kentaro</creatorcontrib><creatorcontrib>Yamazaki, Emi</creatorcontrib><creatorcontrib>Tamabuchi, Erika</creatorcontrib><creatorcontrib>Kuroki, Shigeru</creatorcontrib><creatorcontrib>Kambayashi, Yumi</creatorcontrib><creatorcontrib>Hashimoto, Akira</creatorcontrib><creatorcontrib>Asano, Yoshihide</creatorcontrib><title>Radiation‐induced cutaneous squamous cell carcinoma showing a significant response to pembrolizumab: A case report</title><title>Journal of dermatology</title><addtitle>J Dermatol</addtitle><description>Cutaneous squamous cell carcinoma (cSCC) arising from radiation dermatitis has a higher risk of metastasis than conventional cSCC. Immunosuppression is another risk factor for cSCC, suggesting that mycosis fungoides (MF) could be a risk factor for cSCC. Here we report a case of radiation‐induced cSCC with a high level of tumor‐mutation burden that developed in a patient with MF who was successfully treated with pembrolizumab. The present case suggests that pembrolizumab might be an optimal therapy for radiation‐induced cSCC, even at advanced stages.</description><subject>Aged</subject><subject>Antibodies, Monoclonal, Humanized - adverse effects</subject><subject>Antibodies, Monoclonal, Humanized - therapeutic use</subject><subject>Antineoplastic Agents, Immunological - adverse effects</subject><subject>Antineoplastic Agents, Immunological - therapeutic use</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - drug therapy</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Case reports</subject><subject>Dermatitis</subject><subject>Humans</subject><subject>Immunosuppression</subject><subject>Male</subject><subject>Metastases</subject><subject>Mycosis</subject><subject>Mycosis fungoides</subject><subject>Mycosis Fungoides - diagnosis</subject><subject>Mycosis Fungoides - drug therapy</subject><subject>Mycosis Fungoides - pathology</subject><subject>Neoplasms, Radiation-Induced - diagnosis</subject><subject>Neoplasms, Radiation-Induced - drug therapy</subject><subject>Neoplasms, Radiation-Induced - etiology</subject><subject>Neoplasms, Radiation-Induced - pathology</subject><subject>Pembrolizumab</subject><subject>radiation‐induced cSCC</subject><subject>Risk factors</subject><subject>Skin - pathology</subject><subject>Skin - radiation effects</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - drug therapy</subject><subject>Skin Neoplasms - etiology</subject><subject>Skin Neoplasms - pathology</subject><subject>Squamous cell carcinoma</subject><subject>Treatment Outcome</subject><issn>0385-2407</issn><issn>1346-8138</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctKxDAUhoMoOl7W7iTgxk2d3NpJ3cl4RxBE1yFN0zHSJjVpGcaVj-Az-iSmVl24MZscku_8nP_8AOxjdIzjmWLKsoRjyo_xjBC8Bia_L-tggihPE8LQbAtsh_CMEMlTjDbBFuUZyWeITEB3L0sjO-Psx9u7sWWvdAlV30mrXR9geOllMxRK1zVU0itjXSNheHJLYxcwVmZhTWWUtB30OrTOBg07B1vdFN7V5rVvZHECT2Nz_PC6db7bBRuVrIPe-753wOPF-cP8Krm9u7yen94mipIUJ7OcalZkhco4r4poBhdEpbRCPJdVxlRZIs4RLnWZa5kyokieoZxk0SciTEm6A45G3da7l16HTjQmDE5Gd4IihighDPOIHv5Bn13vbZxOUEwoztKcs0hNR0p5F4LXlWi9aaRfCYzEEIgY1i-G9YuvQGLHwbduXzS6_OV_EohAOgJLU-vVf3ri5ux8FP4EHoiWXA</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Takahashi‐Watanabe, Manami</creator><creator>Fujimura, Taku</creator><creator>Amagai, Ryo</creator><creator>Ohuchi, Kentaro</creator><creator>Yamazaki, Emi</creator><creator>Tamabuchi, Erika</creator><creator>Kuroki, Shigeru</creator><creator>Kambayashi, Yumi</creator><creator>Hashimoto, Akira</creator><creator>Asano, Yoshihide</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6809-5833</orcidid><orcidid>https://orcid.org/0009-0008-3337-5657</orcidid><orcidid>https://orcid.org/0000-0003-3866-5609</orcidid></search><sort><creationdate>202411</creationdate><title>Radiation‐induced cutaneous squamous cell carcinoma showing a significant response to pembrolizumab: A case report</title><author>Takahashi‐Watanabe, Manami ; Fujimura, Taku ; Amagai, Ryo ; Ohuchi, Kentaro ; Yamazaki, Emi ; Tamabuchi, Erika ; Kuroki, Shigeru ; Kambayashi, Yumi ; Hashimoto, Akira ; Asano, Yoshihide</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3251-793e4b6bc688fb0381b2c53f089af64cdd08801ded9ea542c2960926002024ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Antibodies, Monoclonal, Humanized - adverse effects</topic><topic>Antibodies, Monoclonal, Humanized - therapeutic use</topic><topic>Antineoplastic Agents, Immunological - adverse effects</topic><topic>Antineoplastic Agents, Immunological - therapeutic use</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - drug therapy</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Case reports</topic><topic>Dermatitis</topic><topic>Humans</topic><topic>Immunosuppression</topic><topic>Male</topic><topic>Metastases</topic><topic>Mycosis</topic><topic>Mycosis fungoides</topic><topic>Mycosis Fungoides - diagnosis</topic><topic>Mycosis Fungoides - drug therapy</topic><topic>Mycosis Fungoides - pathology</topic><topic>Neoplasms, Radiation-Induced - diagnosis</topic><topic>Neoplasms, Radiation-Induced - drug therapy</topic><topic>Neoplasms, Radiation-Induced - etiology</topic><topic>Neoplasms, Radiation-Induced - pathology</topic><topic>Pembrolizumab</topic><topic>radiation‐induced cSCC</topic><topic>Risk factors</topic><topic>Skin - pathology</topic><topic>Skin - radiation effects</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Skin Neoplasms - drug therapy</topic><topic>Skin Neoplasms - etiology</topic><topic>Skin Neoplasms - pathology</topic><topic>Squamous cell carcinoma</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takahashi‐Watanabe, Manami</creatorcontrib><creatorcontrib>Fujimura, Taku</creatorcontrib><creatorcontrib>Amagai, Ryo</creatorcontrib><creatorcontrib>Ohuchi, Kentaro</creatorcontrib><creatorcontrib>Yamazaki, Emi</creatorcontrib><creatorcontrib>Tamabuchi, Erika</creatorcontrib><creatorcontrib>Kuroki, Shigeru</creatorcontrib><creatorcontrib>Kambayashi, Yumi</creatorcontrib><creatorcontrib>Hashimoto, Akira</creatorcontrib><creatorcontrib>Asano, Yoshihide</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takahashi‐Watanabe, Manami</au><au>Fujimura, Taku</au><au>Amagai, Ryo</au><au>Ohuchi, Kentaro</au><au>Yamazaki, Emi</au><au>Tamabuchi, Erika</au><au>Kuroki, Shigeru</au><au>Kambayashi, Yumi</au><au>Hashimoto, Akira</au><au>Asano, Yoshihide</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiation‐induced cutaneous squamous cell carcinoma showing a significant response to pembrolizumab: A case report</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2024-11</date><risdate>2024</risdate><volume>51</volume><issue>11</issue><spage>1500</spage><epage>1503</epage><pages>1500-1503</pages><issn>0385-2407</issn><issn>1346-8138</issn><eissn>1346-8138</eissn><abstract>Cutaneous squamous cell carcinoma (cSCC) arising from radiation dermatitis has a higher risk of metastasis than conventional cSCC. Immunosuppression is another risk factor for cSCC, suggesting that mycosis fungoides (MF) could be a risk factor for cSCC. Here we report a case of radiation‐induced cSCC with a high level of tumor‐mutation burden that developed in a patient with MF who was successfully treated with pembrolizumab. The present case suggests that pembrolizumab might be an optimal therapy for radiation‐induced cSCC, even at advanced stages.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38629702</pmid><doi>10.1111/1346-8138.17221</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-6809-5833</orcidid><orcidid>https://orcid.org/0009-0008-3337-5657</orcidid><orcidid>https://orcid.org/0000-0003-3866-5609</orcidid></addata></record> |
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subjects | Aged Antibodies, Monoclonal, Humanized - adverse effects Antibodies, Monoclonal, Humanized - therapeutic use Antineoplastic Agents, Immunological - adverse effects Antineoplastic Agents, Immunological - therapeutic use Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Case reports Dermatitis Humans Immunosuppression Male Metastases Mycosis Mycosis fungoides Mycosis Fungoides - diagnosis Mycosis Fungoides - drug therapy Mycosis Fungoides - pathology Neoplasms, Radiation-Induced - diagnosis Neoplasms, Radiation-Induced - drug therapy Neoplasms, Radiation-Induced - etiology Neoplasms, Radiation-Induced - pathology Pembrolizumab radiation‐induced cSCC Risk factors Skin - pathology Skin - radiation effects Skin Neoplasms - diagnosis Skin Neoplasms - drug therapy Skin Neoplasms - etiology Skin Neoplasms - pathology Squamous cell carcinoma Treatment Outcome |
title | Radiation‐induced cutaneous squamous cell carcinoma showing a significant response to pembrolizumab: A case report |
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