Radiation‐induced cutaneous squamous cell carcinoma showing a significant response to pembrolizumab: A case report

Cutaneous squamous cell carcinoma (cSCC) arising from radiation dermatitis has a higher risk of metastasis than conventional cSCC. Immunosuppression is another risk factor for cSCC, suggesting that mycosis fungoides (MF) could be a risk factor for cSCC. Here we report a case of radiation‐induced cSC...

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Veröffentlicht in:Journal of dermatology 2024-11, Vol.51 (11), p.1500-1503
Hauptverfasser: Takahashi‐Watanabe, Manami, Fujimura, Taku, Amagai, Ryo, Ohuchi, Kentaro, Yamazaki, Emi, Tamabuchi, Erika, Kuroki, Shigeru, Kambayashi, Yumi, Hashimoto, Akira, Asano, Yoshihide
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container_end_page 1503
container_issue 11
container_start_page 1500
container_title Journal of dermatology
container_volume 51
creator Takahashi‐Watanabe, Manami
Fujimura, Taku
Amagai, Ryo
Ohuchi, Kentaro
Yamazaki, Emi
Tamabuchi, Erika
Kuroki, Shigeru
Kambayashi, Yumi
Hashimoto, Akira
Asano, Yoshihide
description Cutaneous squamous cell carcinoma (cSCC) arising from radiation dermatitis has a higher risk of metastasis than conventional cSCC. Immunosuppression is another risk factor for cSCC, suggesting that mycosis fungoides (MF) could be a risk factor for cSCC. Here we report a case of radiation‐induced cSCC with a high level of tumor‐mutation burden that developed in a patient with MF who was successfully treated with pembrolizumab. The present case suggests that pembrolizumab might be an optimal therapy for radiation‐induced cSCC, even at advanced stages.
doi_str_mv 10.1111/1346-8138.17221
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subjects Aged
Antibodies, Monoclonal, Humanized - adverse effects
Antibodies, Monoclonal, Humanized - therapeutic use
Antineoplastic Agents, Immunological - adverse effects
Antineoplastic Agents, Immunological - therapeutic use
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - drug therapy
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - therapy
Case reports
Dermatitis
Humans
Immunosuppression
Male
Metastases
Mycosis
Mycosis fungoides
Mycosis Fungoides - diagnosis
Mycosis Fungoides - drug therapy
Mycosis Fungoides - pathology
Neoplasms, Radiation-Induced - diagnosis
Neoplasms, Radiation-Induced - drug therapy
Neoplasms, Radiation-Induced - etiology
Neoplasms, Radiation-Induced - pathology
Pembrolizumab
radiation‐induced cSCC
Risk factors
Skin - pathology
Skin - radiation effects
Skin Neoplasms - diagnosis
Skin Neoplasms - drug therapy
Skin Neoplasms - etiology
Skin Neoplasms - pathology
Squamous cell carcinoma
Treatment Outcome
title Radiation‐induced cutaneous squamous cell carcinoma showing a significant response to pembrolizumab: A case report
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