Radiation‐induced cutaneous squamous cell carcinoma showing a significant response to pembrolizumab: A case report

Cutaneous squamous cell carcinoma (cSCC) arising from radiation dermatitis has a higher risk of metastasis than conventional cSCC. Immunosuppression is another risk factor for cSCC, suggesting that mycosis fungoides (MF) could be a risk factor for cSCC. Here we report a case of radiation‐induced cSC...

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Veröffentlicht in:	Journal of dermatology 2024-11, Vol.51 (11), p.1500-1503
Hauptverfasser:	Takahashi‐Watanabe, Manami, Fujimura, Taku, Amagai, Ryo, Ohuchi, Kentaro, Yamazaki, Emi, Tamabuchi, Erika, Kuroki, Shigeru, Kambayashi, Yumi, Hashimoto, Akira, Asano, Yoshihide
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antibodies, Monoclonal, Humanized - adverse effects Antibodies, Monoclonal, Humanized - therapeutic use Antineoplastic Agents, Immunological - adverse effects Antineoplastic Agents, Immunological - therapeutic use Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Case reports Dermatitis Humans Immunosuppression Male Metastases Mycosis Mycosis fungoides Mycosis Fungoides - diagnosis Mycosis Fungoides - drug therapy Mycosis Fungoides - pathology Neoplasms, Radiation-Induced - diagnosis Neoplasms, Radiation-Induced - drug therapy Neoplasms, Radiation-Induced - etiology Neoplasms, Radiation-Induced - pathology Pembrolizumab radiation‐induced cSCC Risk factors Skin - pathology Skin - radiation effects Skin Neoplasms - diagnosis Skin Neoplasms - drug therapy Skin Neoplasms - etiology Skin Neoplasms - pathology Squamous cell carcinoma Treatment Outcome
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Zusammenfassung:	Cutaneous squamous cell carcinoma (cSCC) arising from radiation dermatitis has a higher risk of metastasis than conventional cSCC. Immunosuppression is another risk factor for cSCC, suggesting that mycosis fungoides (MF) could be a risk factor for cSCC. Here we report a case of radiation‐induced cSCC with a high level of tumor‐mutation burden that developed in a patient with MF who was successfully treated with pembrolizumab. The present case suggests that pembrolizumab might be an optimal therapy for radiation‐induced cSCC, even at advanced stages.
ISSN:	0385-2407 1346-8138 1346-8138
DOI:	10.1111/1346-8138.17221