Temperature-Dependent Divergent Cyclopentadiene Synthesis through Cobalt-Catalyzed C–C Activation of Cyclopropenes

We report a temperature-dependent divergent approach to synthesize multisubstituted cyclopentadienes through cobalt-catalyzed carbon–carbon (C–C) bond activation of cyclopropenes and ring expansion with internal alkynes. By employing different heating procedures, two cyclopentadiene substitution iso...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2024-04, Vol.26 (16), p.3413-3418
Hauptverfasser: Zeng, Tianlong, Li, Ying, Wang, Ruobin, Zhu, Jun
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:We report a temperature-dependent divergent approach to synthesize multisubstituted cyclopentadienes through cobalt-catalyzed carbon–carbon (C–C) bond activation of cyclopropenes and ring expansion with internal alkynes. By employing different heating procedures, two cyclopentadiene substitution isomers were efficiently and selectively constructed. This reaction does not require preactivation of the metal catalyst or additional reducing reagents. Preliminary mechanistic investigations suggest that the key steps are oxidative addition of the cyclopropene to cobalt catalyst, followed by alkyne insertion and 1,5-ester shift.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.4c00959