Risk assessment of feed components of botanical origin – Approaches taken in the European Union

In view of a continuous trend in replacing synthetic feed additives and especially flavouring compounds by botanical preparations, different aspects of the safety evaluations of plants and plant-derived preparations and components in feed are discussed. This includes risk assessment approaches developed by the European Food Safety Authority (EFSA) for phytotoxins regarding unintentional exposure of target animals and of consumers to animal derived food via carry-over from feed. Relevant regulatory frameworks for feed additives and feed contaminants in the European Union are summarised and the essentials of existing guidelines used in the safety evaluation of botanicals and their preparations and components in feed are outlined. The examples presented illustrate how the safety of the botanicals, their preparations and components present in feed is assessed. An outlook on possible future developments in risk assessment by applying new in vitro and in silico methodologies is given. •Risk Assessment of Feed Components of Botanical Origin – Approaches taken in the European Union –.•Guidances for the safety evaluation of botanical feed additives and examples.•Risk assessment of plant-derived components with known genotoxic properties.•Application of the “component-based approach” and the “whole mixture approach”•Future developments by applying “new approach methodologies“ and in silico methods.