Sacral-Nerve-Sparing Planning Strategy in Pelvic Sarcomas/Chordomas Treated with Carbon-Ion Radiotherapy

Sacral-Nerve-Sparing Planning Strategy in Pelvic Sarcomas/Chordomas Treated with Carbon-Ion Radiotherapy

To minimize radiation-induced lumbosacral neuropathy (RILSN), we employed sacral-nerve-sparing optimized carbon-ion therapy strategy (SNSo-CIRT) in treating 35 patients with pelvic sarcomas/chordomas. Plans were optimized using Local Effect Model-I (LEM-I), prescribed D (median dose to HD-PTV) = 73....

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Veröffentlicht in:Cancers 2024-04, Vol.16 (7), p.1284
Hauptverfasser: Nachankar, Ankita, Schafasand, Mansure, Hug, Eugen, Martino, Giovanna, Góra, Joanna, Carlino, Antonio, Stock, Markus, Fossati, Piero
Format: Artikel
Sprache:eng
Schlagworte:
Carbon
Chemotherapy
Denosumab
Diabetes
Ethics
Hypoxia
Medical imaging
Medical prognosis
Morbidity
Nerves
Neuropathy
Patients
Planning
Radiation therapy
Radiotherapy
Sacrum
Sarcoma
Sciatic nerve
Surgery
Survival
Toxicity
Tumors
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Zusammenfassung:To minimize radiation-induced lumbosacral neuropathy (RILSN), we employed sacral-nerve-sparing optimized carbon-ion therapy strategy (SNSo-CIRT) in treating 35 patients with pelvic sarcomas/chordomas. Plans were optimized using Local Effect Model-I (LEM-I), prescribed D (median dose to HD-PTV) = 73.6 (70.4-76.8) Gy (RBE)/16 fractions. Sacral nerves were contoured between L5-S3 levels. D to 5% of sacral nerves-to-spare (outside HD-CTV) (D ) were restricted to
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers16071284