Quantitative Foot Muscle Magnetic Resonance Imaging Reliably Measures Disease Progression in Children and Adolescents with Charcot–Marie–Tooth Disease Type 1A

Quantitative Foot Muscle Magnetic Resonance Imaging Reliably Measures Disease Progression in Children and Adolescents with Charcot–Marie–Tooth Disease Type 1A

Quantitative muscle fat fraction (FF) responsiveness is lower in younger Charcot–Marie–Tooth disease type 1A (CMT1A) patients with lower baseline calf‐level FF. We investigated the practicality, validity, and responsiveness of foot‐level FF in this cohort involving 22 CMT1A patients and 14 controls....

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Veröffentlicht in:Annals of neurology 2024-07, Vol.96 (1), p.170-174
Hauptverfasser: Doherty, Carolynne M., Howard, Paige, O'Donnell, Luke F., Zuccarino, Riccardo, Wastling, Stephen, Milev, Evelin, Banks, Tina, Shah, Sachit, Zafeiropoulos, Nick, Stephens, Katherine J., Sarkozy, Anna, Grider, Tiffany, Feely, Shawna M. E., Manzur, Adnan, Shy, Rosemary R., Skorupinska, Mariola, Pipis, Menelaos, Nicolaisen, Emma, McDowell, Amy, Dilek, Nuran, Rossor, Alexander M., Laura, Matilde, Clark, Christopher, Muntoni, Francesco, Thedens, Daniel, Thornton, John, Morrow, Jasper M., Shy, Michael E., Reilly, Mary M.
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers
Charcot-Marie-Tooth disease
Clinical trials
Feet
Magnetic resonance imaging
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Zusammenfassung:Quantitative muscle fat fraction (FF) responsiveness is lower in younger Charcot–Marie–Tooth disease type 1A (CMT1A) patients with lower baseline calf‐level FF. We investigated the practicality, validity, and responsiveness of foot‐level FF in this cohort involving 22 CMT1A patients and 14 controls. The mean baseline foot‐level FF was 25.9 ± 20.3% in CMT1A patients, and the 365‐day FF (n = 15) increased by 2.0 ± 2.4% (p 
ISSN:0364-5134
1531-8249
1531-8249
DOI:10.1002/ana.26934