Comparison between Two Different Synthesis Methods of Strontium-Doped Hydroxyapatite Designed for Osteoporotic Bone Restoration

Development of efficient controlled local release of drugs that prevent systemic side effects is a challenge for anti-osteoporotic treatments. Research for new bone-regeneration materials is of high importance. Strontium (Sr) is known as an anti-resorptive and anabolic agent useful in treating osteo...

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Veröffentlicht in:Materials 2024-04, Vol.17 (7), p.1472
Hauptverfasser: Codrea, Cosmin Iulian, Lincu, Daniel, Atkinson, Irina, Culita, Daniela C, Croitoru, Alexa-Maria, Dolete, Georgiana, Trusca, Roxana, Vasile, Bogdan Stefan, Stan, Miruna Silvia, Ficai, Denisa, Ficai, Anton
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Sprache:eng
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Zusammenfassung:Development of efficient controlled local release of drugs that prevent systemic side effects is a challenge for anti-osteoporotic treatments. Research for new bone-regeneration materials is of high importance. Strontium (Sr) is known as an anti-resorptive and anabolic agent useful in treating osteoporosis. In this study, we compared two different types of synthesis used for obtaining nano hydroxyapatite (HA) and Sr-containing nano hydroxyapatite (SrHA) for bone tissue engineering. Synthesis of HA and SrHA was performed using co-precipitation and hydrothermal methods. Regardless of the synthesis route for the SrHA, the intended content of Sr was 1, 5, 10, 20, and 30 molar %. The chemical, morphological, and biocompatibility properties of HA and SrHA were investigated. Based on our results, it was shown that HA and SrHA exhibited low cytotoxicity and demonstrated toxic behavior only at higher Sr concentrations.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma17071472