A dynamic regulatory switch for phase separation of FUS protein: Zinc ions and zinc finger domain

Zinc is an important trace element in the human body, and its homeostasis is closely related to amyotrophic lateral sclerosis (ALS). Cytoplasmic FUS proteins from patients with ALS aggregate their important pathologic markers. Liquid-liquid phase separation (LLPS) of FUS can lead to its aggregation....

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Veröffentlicht in:	Biochemical and biophysical research communications 2024-05, Vol.710, p.149862, Article 149862
Hauptverfasser:	Chen, Yatao, Pei, Xiaoying, Chen, Long, Chen, Liming
Format:	Artikel
Sprache:	eng
Schlagworte:	FUS Stress granules Zinc finger
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