Lipidomes define immune cell identity

Lipidomes define immune cell identity

Diverse, specialized immune cells defend against pathogens and cancer cells. A new study reveals the comprehensive lipid compositions of these cells, with unique lipidomes associated with various immune cell types. They show that cell-specific lipid compositions determine a key functional phenotype:...

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Veröffentlicht in:Nature cell biology 2024-04, Vol.26 (4), p.516-518
Hauptverfasser: Levental, Kandice R., Henry, Whitney S.
Format: Artikel
Sprache:eng
Schlagworte:
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Biology
Biomedical and Life Sciences
Cancer
Cancer Research
Cell Biology
Cell death
Cholesterol
Composition
Developmental Biology
Ferroptosis
Immune system
Life Sciences
Lipid peroxidation
Lipids
Lymphocytes
Mass spectrometry
Membranes
News & Views
news-and-views
Pathogens
Phenotypes
Physiology
Plasma
Proteins
Scientific imaging
Stem Cells
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Beschreibung
Zusammenfassung:Diverse, specialized immune cells defend against pathogens and cancer cells. A new study reveals the comprehensive lipid compositions of these cells, with unique lipidomes associated with various immune cell types. They show that cell-specific lipid compositions determine a key functional phenotype: their susceptibility to ferroptosis.
ISSN:1465-7392
1476-4679
1476-4679
DOI:10.1038/s41556-024-01398-8