Utilization of older deceased donors for pediatric liver transplant may negatively impact long‐term survival

Background Multiple adult studies have investigated the role of older donors (ODs) in expanding the donor pool. However, the impact of donor age on pediatric liver transplantation (LT) has not been fully elucidated. Methods UNOS database was used to identify pediatric (≤18 years) LTs performed in th...

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Veröffentlicht in:Journal of pediatric gastroenterology and nutrition 2024-04, Vol.78 (4), p.898-908
Hauptverfasser: Kulkarni, Sakil S., Vachharajani, Neeta A., Hill, Angela L., Kiani, Amen Z., Stoll, Janis M., Nadler, Michelle L., Chapman, William C., Doyle, Maria M., Khan, Adeel S.
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Sprache:eng
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Zusammenfassung:Background Multiple adult studies have investigated the role of older donors (ODs) in expanding the donor pool. However, the impact of donor age on pediatric liver transplantation (LT) has not been fully elucidated. Methods UNOS database was used to identify pediatric (≤18 years) LTs performed in the United States during 2002–22. Donors ≥40 years at donation were classified as older donors (ODs). Propensity analysis was performed with 1:1 matching for potentially confounding variables. Results A total of 10,024 pediatric liver transplantation (PLT) patients met inclusion criteria; 669 received liver grafts from ODs. Candidates receiving OD liver grafts were more likely to be transplanted for acute liver failure, have higher Model End‐Stage Liver Disease/Pediatric End‐Stage Liver Disease (MELD/PELD) scores at LT, listed as Status 1/1A at LT, and be in the intensive care unit (ICU) at time of LT (all p 
ISSN:0277-2116
1536-4801
DOI:10.1002/jpn3.12106